Part I: The Classification Challenge (FAB vs. WHO)

University:
Colorado State University
Course:
BIOL 100 | Principles of Biology
Academic year:

2024
Views:

142

Pages:

1
Author:

Jane Angel Crizaldo

NAME: YEAR AND SECTION: Part I: The Classification Challenge (FAB vs. WHO) Refer to the diagnostic criteria established by both the French-American-British and World Health Organization systems to answer the following. 1. What is the minimum percentage of bone marrow blasts required to diagnose acute leukemia according to the FAB classification versus the WHO classification? 2. A patient presents with a high incidence of Disseminated Intravascular Coagulation (DIC). Their bone marrow shows a predominance of "faggot cells" (promyelocytes with bundles of Auer rods). ○ What is the FAB classification for this leukemia? ○ What is the characteristic chromosomal translocation associated with this subtype? 3. Compare the morphology of L1 and L3 Lymphocytic Leukemia. Focus on cell size, symmetry, and the presence of cytoplasmic vacuoles. Part II: Cytochemical Staining Matrix Fill in the expected results and the diagnostic significance for each stain Stain Expected Result Diagnostic Significance / Purpose Differentiates AML from ALL Myeloperoxidase (MPO) Sudan Black B (SBB) Parallels MPO; stains phospholipids/lipids Positive in ALL and FAB M6 Periodic Acid-Schiff (PAS) Non-Specific Esterase (NSE) Marker for Monocytic differentiation TRAP Key marker for Hairy Cell Leukemia Part III Patient Profile: A 62-year-old male presents with extreme splenomegaly and a very high WBC count. 1. If the Leukocyte Alkaline Phosphatase score is significantly low, which chronic condition is most likely? 2. Which specific chromosomal abnormality should you look for to confirm a diagnosis of Chronic Myelocytic Leukemia? 3. How would the LAP score differ if this were a Leukemoid Reaction instead of CML? Part IV True or False: If false, provide the correct information. 1. In Refractory Anemia with Ringed Sideroblasts, ringed sideroblasts must comprise more than 15% of bone marrow nucleated cells. 2. Chronic Myelomonocytic Leukemia is characterized by an absolute monocytosis of less than 1.0 x 10^9/L. 3. The WHO classification reassigns RAEB-T as a chronic leukemia because the blast count is between 20-30%.

Part I: The Classification Challenge (FAB vs. WHO)

Related Documents

Recommended Documents

Description

Related Documents

Almost There!

Free up your schedule!

Take 5 seconds to unlock