Heart Failure - Treatment

Treatment of Heard Failure & Cardios glycosides head forehead fails to pump the blood to peripheral Orgons. Systolic heart failure Impairment of myocardial contrahlily Diastolic heart failus din to falur of heart to rules & collect bleلس which has to be pumped 2 Low output failure metabolic demurels are hond, heart is urable to mut then High →hiet-bolic demands ahe excessive. Chyperthyroidism, anemia ek.) Compensatory responses during heart lobes. 4 inersand sympattuts andwity bution of RASAS - Ventricular remo delling - Myocardial hypatophy Pothophyl. of heand Ale Cardian output A Heart Rek BB/ACE/ARBS Idy mattele activity ↓ Blood pressu Rend Kood flow A Renin ACGIARB Angiotensin Aldostorne AA ruenton. Two distint goals of dung thenpy in heart fleuvre. A. Rebbe of congushe I Low output symphers & leestarction of Cardiac performance 4 Protupic denys - digoin, dobumin, inemeanore Furosemad, thiosids hatolesne RAS inhibitas - Alt inhibihen (ARB) - Hydrazine, hideat, hitro prausia - Synthete BNP - Nesirihd 4 B blaku -Hetoprolol, bisopedd, Carvedilol. B. Arul I reversed of disease progussmen & prolongation of semminad 4 ACE inhibitos AR8s B-blocks. 4 Aldosterone antagonot Neprilysin inhibiha Cardiac glycosides → derngs having candras intropic property → they inveere ryscardial contractility & output in a hypady nowe heout without invewan in O, consumption. Pharmacolegial actors 1. Heart Pore of corruden dos dependent invoon in Sove of conbalan → especially seen in Peking heat Systoles sharkred, double pulonga. + Rete heart ruk is deerwand by digown. →becedy Cando more worked in CHF pekanb (improved membion resheus diminished regel tore. In addition, digitals slows heal by vegel linowe wyl tou) & Cabrivagal (dient depensus of SA & AU modes) ankohe. - Elechophysiologied propuses. All conduction Hoved of therapeute dores. →ECG high doses may produce aralythwes MOA Cardver glyvorer Binds to No-K Атрон стадия in yocarded cells Nat-kt AlPau inhibits Outwards trons his ↓ of sodium from cells Na in clear in cells Augments extings of res to bleum Excers Celeron infles into celts Eran alum Iperes by scandal Kondrachicty Intrafors impeche son I conductor. Inhibition of Mat ki Arpan in valued in fonic actors of digibbs. → at high dous depletion of intracellula kt henave difilebs hocitly is pantally reverend by infusing t Since Ik deereens binding of glyceriole to No Ki ATPass. 2. Blood vesels wek disud base contenchos acties → periphead resistance incercand in hond individuals. 3. Kidny Cours diuras in CHF pokrits "Improveant in rend perfusion. 4. (NS high der (G2 actucher, hyper apnoea. T induce heor high low, hall confuser, visual disturbomes. ALE 4 Candice → Cardiac arrhythmias du to diskabed impulse formson - disturbed impule conduchan Entra candrar gi doscity Anorexa, houses, vomiting abdominl pain. Chos dosicky → valigo, blurring of usein (yellow viven) herdeche confusion desaich miscellanean skin rusha, eosinophile & gymwnate. Terentiunt of digoson tosiuly → Stop digoxin for Locky danythias infuse ked 20m.nl/he . 16 Verlei cula arry htthias lidocaine Iv Supere venter wider arrythmias → Proprerolol AV-block & bedy Canta - Atropine 0.6-1.2 by act. i.m. Digosin Onti bolly Conte intilons →Hypo koleno →Elderly, and or hepta divas > thyrotoxicons → Ventricular tachycardia →Packed Al block. Interaton 1. dientes course hypokaleme which inersen wash of digihls arukything. 2. Coleum Synergises with digildis precepitiko dooxicity 3. Quinidine reduces binding of digovin to disse proky. Lence plass cone doubles foxity. 4. Adrenery, drys induce aralythias in digitalised potins 5. Agesin alasaptan rudwed by hato dopramide, sucealth, anteces