Thyroid Related Drugs

Thyred hormons & Thyerad Inhibitors. Thyrad hormon synthesis → Involves the following steps. Jodide uptake. → done by Net - Iodide Aymporter (NIS) Stimland by TSH Oxidation & iodinden. Jodide foropped in follicubs cells. corned acres by Pendan → then osidred by membros band thy maid perosidase. enzynu to to iodinion ichs these compire with tyrosin rundus of thyroglobitn * Carpting to for Mu & DIT. 4 Coupling MIT & DIT couple do sam T's & Tu •Periphed 4 Conversh Tu do Ts. (done by indathyronin deiadinose) Physiologial effate of thyroid hormones. → Stimulee puten synthess. promchs abssaphon of duron produins hyper fycemia & diable like toa in hyperthyroidism. tendency to laver serum celesterol lend by enhancing chdestend meteboliom. increan BMR (maindein by Stimably cellules hulbulim → heoat luk, Constructility & output increased. → inuren rok of depth of uspesos. → increase rate of secretion of digestive juives & modlity of GUT. hides Lock excess Thyroid hornas Con of hormons Con of libido impoknce demdes faces →mentahoca / poly hemerorchor →ievregube pred holl amende Relchon between Tu ET3. thyroid scanty more To then To Tu moj or circulating hormone (15 times. Miste dighly bound to plasma prokins 5 fines to protend then Tr mou avidly bound to nuclear receptes then Tu 113rd of Ty converted to Ts in thyroid cells, live, knong lance T's activ e hormone 13 Tu transport ham which ferations as prohormone of Is Uses 1. Gehnism des de feiters of thyroid develop head / defect in hormon synthess. due to extreme indin synthesis. Lifewoney. detakd during infany I childhood. →L-Ayrosine to 12.5 50 ug → torated as carly as possible to restore physical geauth. & development & percent hertther ment retardation." 2. Adult hypothyroidism (myxoedema) Cours thyroiditis, thyroidectomy, →Antibodies against thy Maid perosidre oa Hyroglobulin responsible _ der majonly of o -Thyron de 100-200 mgl day. 3. Hyzvedeme Coma → emerging conditos progressive mental deterioration due do acuto →thy powin hypothyroidism. L-thyroxine 200 - 500 ug iv followed by 100mg in on Li. Non dove garkes → characterised by enlargman of thyroid with enthywind status. →Endemic jodine defisiensy →Sporadic defut in hormone synthers. exces ISH Courses Shyasid enlargener inorcard tropping of iodide & synthesis of 13. remagh do med peripherd demands. 5 Thy maid model. 6. Popillary Corenome of thyroid. 7. Empleied uses Referendary anemias. Mensternal disorders - Mental depression. Theyrald inhibbery → Jungs used to lower Senckard coperity of hyperactive thyroid gend. Thystericoris --> der so excessive secution of thyroid hormones. > two mein Grove's disease & baie hodulas goiter. Clessification Inhibil hormone Inhibat, adide Inhibihans Synthesis (Ionic inhintory) Thoamdy Dessway thyroid y Propylthiouroul Thioyoroks Perchlorks Jo dire Judices of No, k Redio acho jodine y Methimazole 4 Nitrons Organic iodide 7 Corbi mozole Thioamides (Antithy roid deugs) →thiogmides bind to the thyroid perosiden & perevent jadid & iodoly Mosyl residues, hener (1) inhibit iodinden of fyndin residues in thyroglobulin (ii) inhibid couplry of indotyraine resideen to fam T3&T4. Propylthioureesl Corbimazole → dose do don less podent → Aboud & fimus how poend highly plesome preskin bound Lus bound. 7 less benetand across placendo Evite → ledige amount bross to fextus & in will → plasmo tip 1-2 hows 6-10 has →no active huboboise → peroduces actix melobact → multiple daily doves needed huthimazole →ustly single daily dose. inhibits peripherl conversion →no inhibiker of periphal Conversion. of Tuto Ts Advers ts > hypothyradion and goids con orus due to over treatment. 7 skin reshe, jou pein Liver dene gel especially propyl thioureel) Uses → control theyre basicosis in graves as well as dove podules gak. - improvement slats in 1-2 weeks → can be used as a definite therapy for graves disease & Daic noduler goida. preoperatively patients bendured enstyered with corbimo zde before po performing tigeroidectory → along with redroatia iodine Advantages aur Sungry & 131 I surgical eusk, sras, chances of injury hypothyroidism il indued is reversible. → Can be und in children & young adults. di sadvantages → perdored tradend needed; eculapses are high. →nd pereft preacticate in unco-operate petere deng brity. Jonic Inhibitors imhübil iodine tepping → Tosse & clinically hol applicake. Jodin & Jedides inhibit hormone relean. → that rapidly acting and thyroid deugs. → Meparators tugas iadine (5% iodine + 10% kel) → in quours disease less Vasuba. T gland if enlarged, sharinks becomes firm & thyroid gland invscuns & edloid is restored. Uses Preoperphine ly • makes dond Sor thyroidery in gend hrm, less vascular gleave's dipan. T doase symptors, Sharinks the gland. to operate, reduces Pasier to → thyrad stam: "tugd's lodive und do stop furtha ruler of T3/T4 Suom thynod & deerean Tis to Ts conversion → prophyles of endemic gords.. Advan fute → Acute reacher → Swelling of lips, eyelids, angioedema of larynx kua, jo pane > chronic overdose inflemmolon of mucous membranes, salivakis, Ciodism) Sheering, brimcha Radio active iodine (13) Yoys as well as B parkles (elations) useful in trecer Audies On thyouand cells. Couses cell followed by Iberoos, ho domage to Leighbouring cells." Sedum salt of og dissolued in wake & given orally.