University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

99

Pages:

6
Author:

Badusha S.

Diebtes Mellitu Insulin →Metabole disorda charachand by hyperglycone, glywesia, by hypalipiderma, negative nikogen badence & ketonecau. Closshed into Type: Inadin dependent dodades milles Type 2: Non-, nsulin dependent diabetes mellikes Insulin increases uptake & storage of quiere Stimuleks glycogenesis inhibit Ipolyss. Promotes fot uptake & share. increases protein synthesis. Mechanism & Achon Binding insulin do & Subuns aggregation & internetisctor of recepts along with insulin hide whes achuets tyrosine karese Cascade of phosphorylaten & dephosphorylater breactions in volving P13 kinose Shimpher inhibitos enzynes achers of insulin invoked in bulbol Fate & Insulin peped degraded in GIT it given orally. metbolaed poimarily in liver Prepareters of insulin Rapid auding Short arting Internudiah acting y Insulin lispero 4 Regules (soluble) insutn Insuln zin Suspensia (Lente) 7 Insulin aspart - Inslubin glulisive tong anding. Insulin glargin 4 Neutral pacotamine bayadorn (NPH) Insulin devermir. highly peeriked Insulins Louro- Porcine, Puwihied ion exchange checomuto geophy - Single peck & Maccompan gel Alteader, →less allergy, here Sek, less chance of resistere & lipodystrophy → expensive. Types of insulin preparatas Regules I soluble insulin y fende insulin (insulin zine supersen) Isophon (NPH) insulin. Regube soluble imun infectable soluten-farms hesomes around zine is → after sic inj mononurs released slavy. → peck auton - 2-3 has duration of Auton 6-8 has. optimally injected the befor wed Only snoulin used iv. Lende inouta → formulated to dissdur gradually Longs duration of Action. AC once daily or twice daily. Isophone (NPH) Imanlin Protomne is added in a quandly just sufficient to complemlall maulin mdicules. sc injeka, Complex dissociates stoly to yield an intermediate Aurden of action. combined with sugules indin (10:30 9 50.50) & injuded Sc file daily befor breakfor dinner. Humor neutro > produced by recombinant DNA techndegy or enzymat mabhat of porcine insulin. → expensive less immunogene, dess required is lesser. → Indirahas - allergy to comentand, insulin resisterer, Ipodpatkups, pregnary. Insula andagus → recombinant DNA dubadagy absabed 3 times Packe 5010 mim → leser chance of hypoglycemia. Advers reactans I by polycemia may be cound by large den, musing a mil vigoresan cacher Symplams- autonomic symptoms sweetry, dremers, tachycanda, anest neuroglycopenic symptome confusion & drowsinur Li0 mylds - Comulson & can Tredmodoul glucose 15-20g reversus segmeption. 15,20 min → if no impravend, Same Severe cose In glucose. amant repeshid alta Low reasons due to insulin allergy. 2 →itching redress, swelling, rophylactic shock. lipodyskoply al injeder sider 3 Edene Drug Interations 1. Bete blocker hypoglycemic signs 2. Thipziel, drasend, Corticosteroids, OCP, I blood sugar. 3. heavy aliced consumptor ppt hypoglycence. 4. Lithium, theophyllin, high dos aspirin - ppt hypoglycemia. -