University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

333

Pages:

6
Author:

Badusha S.

Oral Antidiabeke Drugs Enhance insulin Sevution KAIP channel blockers ireas Tolbutonell Gliben demide Gliclazide 4 Glimepiride Overtow insulin resistence Thiozdedindishe Pioglitazone By quanid Dipiphdyl pephden-4 inhibidors Y Vildaglipan. Phenyl aloniv Analogues daragliptin Repaglinide Teneliğiptin Nateglinide "Dopagliflozin Conagli Slozin Retard Carbohydrat absapher L-glucosidose inhibites Acarber Miglidel Miscelloness & Vraglibose Sa27-2 inhibida Dopemis • Integonat antegonat 4 Bromocription. Y Sulfonylureas MOA Bind de sallowfures recepts (SURI) Located os ponerectic Bcell membrane block k chonnels ↓ Stimble sculasse of insulin ↓ onduces blood glucose. increase sen Extro pancreste artion increase sensitivity of peripheral dissues do insulin increase no of insulin receptas → Seppereses Quconeogenesis in liver. Drug interactors dengs that enhance Sus action → Displeie from perakin binding Phenyl butazore, salicy wes, Sultonawds →mhibit metabolim cimetidine, ketoconazol, sulfonamids warkrin, alcohol. Synergise salicifeks, propranold, theophylline Drugs that deerer Su, auth. → induce melobodson phenobarbison phenytoin eritempr → oppaite alen corticosteroicu, thiczid, OCRs. Thiazdi dine dione Pro glitozs → perosisane perdiforata achuched recepta) agonist. → enhanes transcription of insulin resssance. insulin responsible genes & dends to reverse saiphan of insulin respe by enhancing GLUTH expresion E trondocoche. →heme increase insulin redialed glucon transport (GLUT-4) into mushes & fot fissen. → reduce hepatic glucomogenesis.. ALG weight fo oneca, edene conwoven CCF L- glucolindex inhibitors inhibit digestion of starch & disacharides by competitively inhibing intestinal -glucosidase. enduce post prandid blood glucose louds. ALE gl disturbances in IBD & rond impairment. Dipeptidy peptidon 14 COPP-4) inhibitors DPP L plays a key ude in rapid degradera of GLP-1 DPP-4 inhibitors potentiale the author of GLP-18 GIP. → boste pot perandial msulin release, deverans qucagon secrations. →lowers hud time & lesbing bloed glaas lands Sodim-glucose co-transport -2 inhibitor > glucon Altered at the glomerulis reabsorbed SGLT-2 in Pa > whose inhibition induces glyrasuria & lowers blod glucan → Dopglilozin & Congliflozin ary for use in type 2 DM. the SGLT-2 inhales apprand → Athar once daly doing, produce rond the clock glycama. → Concerns Can predispose de urinary & genital infections, eletrolyte imbdance, ketoanders & increused coinars frequency.