University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

463

Pages:

6
Author:

Badusha S.

Corticosteroids Minadocaticoid hors principal acties enhancement of Nest reabsorption Suom DCT in kidney in kt & ut excretion. Glucocorticoid action 1. Carboky deck & perotein natobolim hyperglycom resistence to insulin & a diabetes like state. 4 induong hepatic glycogen synthers. 4 promote gluestes genesis. inhibit glucose utilisation by periphal issues. → protein breakdown & Amino and heatsilschon deom peripherd tissues- muscle washing, les of osteoid hom bone a thinning of skin/ herve the omπο aids habilised dunud into lives wed in gluco hesgeness, laces urse is produced begative hitrogen bolence 2 Fat Hetabolism → promote lipolysu → redistributor of let kom peripherd stores to contel - Contrepetol Obesity. → Facet hoon for fish mouth →bulfello how. 3. Calium hutebolim → inhibit intestinal obsaphen & enhance eund excretes. → loss of Celsium suam bas (osteoperass) → Spongly bones. 4. CUS → restrict pollry permeability → maintain dave of arteriales & myocardid contro lility permisive effect on pressor auton of Adr & angiolinon 5. Skebeld musles → ophirum level weeded & pernil muscular activity hypocash com diminished work coperity & weaknen den to Lyrodynamic circuitor hyper corticom excess minerocorticoid funder hypokelewe waknes → excers glucocorticoid alan nuach wasting & myopathy. 6. CNS →hild euphoria increase heater ativity, insomma high doses laver seizeve theshold. 7. Storich JPG.) of gastic and & pepsion aggerante peptic ulier. 8. Lymphad bis & blad cells → enhance ree of destenchon of Cymphoid cells. → increase the humber of RBCs, plebitis & handauphils in Circulda → deerden lymphocyta, eosinophils & basophils 9. Antiflemnulary & immunosuppressor offerte → suppres develophal of inflammatory response to all types heech Chemicel immunologie! → inhibis both early & lede meritatator of inflamator Coppillary predikerer collegen deposit. - scos dans ton delay wound Leading. → inhibit migraten & depress the leches of leukocytes & macrophages & release chemical andidors. → suppress puresdenchen of cytokines. Mechanism of Action Corticosteroids pendents cells. ↓ Bind to high affiroly Cytoplasmic recepta protein ↓ Structural change bleurs in the steroid recepte complex Migration into the nucleus. ↓ Binding to quocorticoid response demets (GRE) The chrautin Tronscription of spechi MRNA ↓ Regulation of proton synthess. Class hoks corticoido Short ang hydrocortiso (Corhid) Internulich Lorng ating Gading Minerlo corticoids - desoxy cortico strupes archs (DOLA) Desa mutho some 4 teethylprednisdire "Beds heathes che 4 Fludrocortisine Y y Aldostane. -Defle cord Therapeutic uses A. Replacement theropes 1) Acute adend insufficency. → Con olem de to - abrupt withdroud of steroid fromat 4 following stress, thoums, sragay → emagery condition. I Memet → Correction of body linds & electrolyte 1V send 51. in houl Sdine hydrocortisone archs 100 mg iv bolus every show. followed by IM Every 6-8 hau Switch to ord hydrocortisone That paripiting caus. (n) Congenital adrenal Lyperplasia. B. Phornewthropy won endocrind couns) Gensered prinsiples to be allowed during threshment + Singh der leven excesive) is not harmful. Clan be und de tide ova morld Cesis) - Short Courses leven high dow) not herufel desene of contraindichas in