University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

404

Pages:

4
Author:

Badusha S.

Tuberculosis →is a communicable, chronic granulomatous disease caused by Mycobactrium Juberubass. Infection indicates peusene of organism in o mey not use Symptomite disease. person, which my s Disease active fuberculars subset of tuberculous infections. hanifisted by desterschre, Symphorate disease. Pathogenesis with Juberde bailli susults in two simultaneous impfpinofragial infchen Mesponse - Cell mulioded immunity Type N hypersensituly reaction. Cell hudald Immunity TB developing find time in an immunocomputer individual depends on CM1. Type W reaction > develops to nyeberkual antigers & esporrible Sa hivu antigens destentor. (Caesating guanndoms & cavilation) Mechanism of gumulon Pro Y actiuntion of CHU Infection before achinta viveulent tubent baiti deposited in the dosue ↓ peinanly infed macrophges Center advedas macrophages by endougtass. thuagh macro phoge receptes) ↓ protikel Henly within progosion of rucrophage block husiano phagoson & lysosome result in baderewa Seeding of bailli at Multiple siks →grach Ada: NRAMPI transmunbeon pention inhibis wowhid gewith. Choked resishme associckad macrophage protein 1) In individuks with polymaphonm TB may progress. in NRAMPI gone, y Initichon & Consequences of CMI → Che develops about 3 weeks after exposun. Prunthan of antigen do COL' T cells. APIS heive process bycobacterial antigen & present it to CD4+ T cells. → processed antigen reeds regional lymph nodes. Ditheantiton of Cou" Tcells iNo THI cells. → due to acten of 12-12 seened by hecrophages. The cells produe M Actiuchen IFN-Y which has several feathers. of necrophages. becom bactericidiel & Search TNF. promote recentes of لی dittaential into epithelbid cells. Abinash hamalan of phagolysesore capar bastırı de arde envient. - No Synthese Crack lente ritugen spevas antibacteriidel. " ROS 4 "Stimulet autopligy. J'al also responsible la foamtion of geomlamas & Asus hevegis. gramflowhers inflemben. Primey Tuberculess 1 →inited infechon the occum on had exposure to the Organism inf of Onsen tied immunocompetent individuel. Morphology. Lung most common Ak. ghan in → following inhabian tubercle beniki gets deposited in the distal Airspores. → site of depus cupy lowa part of upper lobe or upper part of lower lobe, hear pleurd surfor. ghon fors → Circom srecabed Center grey whit aw. of which undergos fabal 1-1.5cm coseous gregional lymphadenitis. ghan couple combination of subplanned pecernibynad lung lewish & Megivent ly with hade involvement.. Fate of ghan comples Hedding → in majority (MI conterds infection & parinay TB hels. hellmark of heling fbrass. →unden gas pragusive Abreos, folland by calefication.. Microscopy gromlome