University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

378

Pages:

3
Author:

Badusha S.

a disease progresses, produce progressive expension & coalexon of lesions bef massive fibras. -> Sullen silicone Lodules coalese to som lery lesions levons and hand, some of the many undings centered solley → fibrot, lesions may also develop in hilas lymph nodes & pleure Siloths hodule →charechastic whorled appearene. → Center wnsists of incendere layers of hyalinud. acellular collegen → periphery Aggregates of mono huckar cells. hustly macrophages, lymphaytes & fibroblas Microscopy 4 Polarised light microscopy Show birefringent silica pantiles in center. Asbestosis →inderstitel Ahrors of the lung caused by espoure do Asbestos dust. Tynes 1. Serpentis ham →chelysdise is the most imported serpentin form of tos asbestos → consists of long, curly, Plesie stendure likely to get impected in the opper respiratory pessages & removed by mucocdiary action. → rudily carried to lungs. Segment into short partiles , even if trapped in lungs. & easily ingated by mocrophage → hay salutke then amphiboles. 2. Amphibole kams main amphibole form Crocidolite Colour asbestos). ames I brown asbestos) consists of straight, migid, brittle Abus align themselves in the airstream & remision stable in the Cung. → neither fragment Na soluble, this reach deeper into eng & peretek epithelial cells & reach the intentiom Pathogeneys Inhaled astertes Pors much macrophones alters to liges Achuck macrophages Our speces E des brus lukose remotech initled injury end thesult Ocurs at bitur coton of Small Gifsays. generebred interstial pulmonary inflammatar a inderstitial fibress. Morphology. Sites lesione hoyin in the lower lobes & subpleuro. carly stages beguns as interstitial fibras around respiratory bromedades & elvedas duch Ceter stages inderstitial Sibrosis becomes mon extensive & may involve the entier lung → fibrous my destiny hond architecture of luy & produe dileted airspues. Surrand by thich brom walls → produce honey combed appearance. Microscopy Asbestos bodies. → consist of translucent Cender of asbestos Abers coated with a film of proteins rich in iron. > appear as golden brown, Susitam or beaded rods. → catry thickus at end of fibers dust-bell appearance. Ferruginou bodies → atha inorganic particulites / fbers also cooled with simulas Iron- protein complexes feruginous bodies.