Lecture Note About Atherosclerosis

Ather sclerosis →Mimarily a progressive disean of indive invaluing lesze E hudrum sized elastic & muscular arteries. characterised by focal lipid rich intind humors alled Atturones. → atheroscleroti usion in Lumen of involved uned. the indive big budur a blod →on rupter to caur sudden occlusion. Risk factors fa Atheroscleross Modifieke moja lisk lachos 1. Hypullipidermia incheer in serum lipils mainly cholestest is hija rich leche. lon inilict athus scheesti lesen. y high levels of 102 inward sush high levels of 1401 decrease rish. → sejun cholestust level skeangly lubid to dictary intake of Sahated fat. Diel which Meives blood cholesterd egg yolks, Grimal lats, butter → frons unsetershad Sats produced by artificial by draginton of PUFA. chet which lowa blood cholestad ovel low in choleukol a high in POFALL Ornga 3 billy ands Chigh in hsh & hoh oilk) • cholested lowery demys (stelins) 2. Hypalension The of the significant luisk factors. nedens of the scleros increas as BP lives. → control of dily puclarion with antihypadasive therapy redves scist of hyocardial infarction & skot. 3. & Cigarette smoking imp auoi deble Caye → Athero seleras won severe & extensive among smukus then hon sheokers. Strony dok linked rubbership bahuwen ciganite smothy & Tischemic heart disease. Le Diabetes Mellitus potent risk luter la atherostera... I dichels associated with hypercholes fedemia. increase list of athens sileir Men modificable, risk factor 1. geneli obrambly taendelion diser des like famtid hypercholesalenio. associated with athassiloritis. 2. Fanly hishey 3. Inerasing ags 4. gradu per muпореш have lowes incidence. Pathogeneprs a Response to inj wy hypothesis. → atheroscleras develops as wall to the endothelid injury. chronic response of the arterid Sequene of pettagenic eunte Chronic endothelial injcery / dysfuntch cysten 1. Endothetat injury Chyperlipidemie, hypa teras, smulking, howwysin) ↓ Elfew of undo thalid injury 1. Leukocyth edhen to endotheliny 2. Incensed vascula Parnus by ling 3. Platelet attosion & Hamboro 4. Maumel of Loks Geras endotheliom isto intime. ↓ Higeston of moroghs indo intina rage ind E lipid accumuleton in de intime.. Formiton foom cells by Enguling lipoproteins & LOL by weroplaga. Migution ↓ smooth muscle cell into indine & produce ECM to sam loom cete. "faction of atherosclerste plequ. Morphology Athuasifrote plaque. color- white to yellow - if super impard by thrombus end brown. Size 0.3 to 1.5cm in dramla -xan Coolesce to bom large masses dromedes. upto 8-12 am in irregula with well defined bordas. Shepe distributas petely, usually invoke inudwed ankend will. aly pakion of th Comperial soft, yellow, gromos core of lipd covered by whk dokous Op. Mias sey. 3 Region 1. Suported bran cop. → lampad of Smooth beach calls & collagen. seen deep to Abron cop. & calons • lipid: abund bipid, hoinly chodisheral & its esmu. Seen as empty sulle shaped cleft-lik spaces y debris from dead cells. fon cells y hiben, thrambus, plom protrs. 3. Shoulch periphol region benith cop -> conbis woowplogs, sok model cell & Teelle. Compliano pleques 1. Ruptur ulceration Orchissed. plap pewtundes into lemon & dishub Hood flow resulting in funkleat thon dange endothelem -> come ruptur, ullouton or chasis of indit sunfar of plaques. 2. Ikmerrtege into pleque. My our den to ruptur of fibean cop of plaque. 3. Thrombses & enebolsm. L.. Athens chobom. 5. Prysm facker. 6. Celer Aption.