University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

437

Pages:

5
Author:

Badusha S.

Tumors of Contreal narvous System Classified •Diffkun astrocytic and digadendrogtial tumors Y liften astrocyte ha IDH hubad, 1074 wild tyre & Nos - aneplache astrocytome: IDH huten, IDH wildtype & Nos Glio boston Oligodendroglion IDIA hudand, 1014 wildtype & Nos Aroplaste oligodendraglione • Other astrolytic tumors - Pilocytic astroytone Y Ependy mome. • Neuronal Jumors. • Embryoul fumers I medulloblostone. Meningiomas Metestatis funos Astro tono Pilocytic astuarydone → grade I Dishun astrorytone grade 11 Aroplastic astrocyton grade 111 Glioblastome →gude N. Molecular gratis. Mulsion in iso citech dehydrogense (101) genes. > occur in IDHI a IDHI gemes leads to increased producer of 2- hydray Jutarate. Judoruke. → which indorfer with activity of enzgaus th reagulat Gene especession. • Mullers in promotes for klonuruse > Causes immortalisohon of lumor cells and can be seen in gliatostomes → In tumors with 10H mulders, telomeres mutalons ar Uncommon → insteed they have loss of bunches in ATRY - Other genetic alterations include → Over expresion of EGF receptos, tyrosin kinese recepto → du sobu p53 PB. Morpedogs 1) Diften askroydon poorly demar and, inftrative en im to leage lesions. quay, dorm a soft gelatinous.. Mickascopy mild to moderate cellularity Vencidole diyer of rudeer pleiarmaphism. → fibustlery background > e ble hules of Sunar cells, extensive notewah of five GFAP the astrocytic procenses. INC imrumno posikiaty sa GFAP (glial Abrillery and pestain). Amoplast astrostore hnickoscopy → increased cellubrity → celluler & bucks pleiomorphism →Anoplasia presence of hitotic figeon → Rapid growth of Suna. Glioblas consistery E color dow areas varies Nareigeled appearsone frem & whis, others soft & yellow due to hecrosis. show cystic degenerts. microscopy → similer de an anoplastic astrocytome with heclass a vasculer I endothelial cell pacliteration. increased cellularity, marked cellula & nuclear pleio map har Aneplesia, Suequat milos. Ependymom tumou arising from ependymal cells morphology gross sold & homogenous as popllery → madurakly will demarcated. Tumour cells. resembre normal ependymal cells. >vericke anand of dense fibrillery background. 4 Rosettes. → ependynd roller Jurmour cells bam gland like Mound a elongated stoentures resanke Ombryologic ependymod corel. → perivos cales pseudo rosches Jumma cells arranged arand vessels to som parivascuber pseudoranthes more frequent shots for ependent rotter.