University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

295

Pages:

3
Author:

Badusha S.

HPV infuhos. → sexually transmited DNA ureus. gisk leckers - multiple sex partrou. 4 fivut inter course at young agr "mule partner with multipe ses partners. Classification of HPV. Lou Oncogenis rich. 4 causes condylomo acuminate periend region in veho prinel & APU genom remains in nonindegenthed due fam. a viveus replireks & cours deuth of the host. → High oncogenic risk. APU 16 & 18 must imp Other HPV 31 & 33. T → also cause squonian cell carcinoma of vagine, vulvo, pems, → intergeration into the host DNA takes plue which couns Overexpression of arco protins L genomic irulability in host cell. Fectures of infulon by MPV Jonger the duration of infukon, higher the risk of CIN & subsequent Corvinom. →HPUS infet immekere basel Cells of squamous epitheliom a immeture maloplastic squamous alls. > infert only damaged surfae epithelium & had inled. Superhoid squamous cells. → Replicator ocers in mokwing ponproliferating squonian cells which are hormally arrested in the G1 phase of the cycle. HPV induce DNA synthesis & Martinde mitotic cycle in such hon pudiferiting cells. Lyleputtic effed - Koileylic alyna → results in Cytopathic effet Chuclear atypia + cytoplasmee parimeless hola) Oncogeness by HPV high rish "HPV types overexpresion of E6 & 67 Oncoprakins →67 prodeun inactivation of RB & inhibition of Cyclin dependent kinese inhibikas. →inecra progression of ell cycle & impor ability do repair DNA donage. →66 protein degradation of sumon superasi p53. leeds to Cell immortalisation. Enviromull fears Presene of co-caringens: Cigarette Shishing. -> Corsisting microbial infectors → Didary deliciencies → Hormond changes Use of and contraceptives.. Classifichon of Cen CIN-T mild dyspira → Las gerd squecian intreepittala Cemer (LSIL) CINI moderate dysplica... HSIL CIN Severe depplesia → Carcinome in siter ASIL.