University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

351

Pages:

4
Author:

Badusha S.

Endo metrons → presence of endomabed fisses outside of the uterus Pathogenes origin of endometriosis y fuam utrine endonubriom y from outside utaus which has Coperly to give love to endonutrid how. theoses 1) Regurgiteder theory → endometrial tissue by retrograde menstruaher passes through fallopian tubes & implented at abnormd siks 11) Benign mutastases theory endomubied hisser spened from ukrus to distort siks ha blood vessels & lymphates. Ai) Mefoplastic theory → endo molerium acizes directly from mdeplora of cobloh pithelium 12) Exprouterine stem cell sheory. Mechanism →endometriotic dissue in but also abnormd. endo rubricis is hd just misploed → they differ from nornd endonubriom in the following ways 4 increased levels of inflammatory mediatorn. strond cells also secret aromatase which fevers Increand local estrogen. productes there fus fectes increm survived & persistence of endometrios tissue in dough locuties. Morphdogy Mode nodules with red-blue to yellow-brown. at the site of endometriosis. appearence → endometriosis of ovary chocolar cyss. 4 ovaries distored by cysthe speces dark brown fluid Lat folled with - rapeded hemorrhage may form large cytes. →Ahaus both endo multid fords & strome with or withad hemanderin den macrophages. Endometrial hyperplasa > inferend thicknes of endometrion due to increand pedipenden of the endometrid glands sulake to the stromo. → incrand glond-to-stro me ratio when compared to norkel endometrim imp cause of abnormal uterine Keeding. → soil for endonubid Corenoma. Ethology - Prolonged estrogen Stimulation due → Inercand estrogen productes *Endogenous sources →Obesity inercand peripheral conversion of androstenedione do estone by enzyme aronder in fat cells. → Polycyshe ovarian diseau → Functioned Exo ginous lo adminiskuter cell summers of Ovay of tumor suppress Gon PTEN. seen in both endometrial hyperplasis & Carcinomas → Loss of PTEN function autructe cellular pathways Classificallion Old class thaten 1. Simple hyperplasia without alypia 2. dimple hyperplasia with alypia 3. Complex hyperplasia without atypa. 4. Complex hypophose with atypia 1. He perplasa without atypia INonatypical hyperplesa. 2. Atypial hyperplasial Endomadaad interepithelial Neoplasiae.