University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

39

Pages:

4
Author:

Badusha S.

Randomization in CT Prown I cusigning treatment gracups. CT ponticipante to . Give each participant a knoum (equal). chance I being to any of the groups Succenjul romdomization - Group nignment Connot be predicted in advance • Confounders - com possibly affect the contiome the study- distributed equally. Eliminate select" bias • Enimes comparabitily Criteria Jos randomization. 1. Unpredictability BUS. • each ponticapent has some chomee g receing any I interention Neither the ponticupent will know in advorme assigned. 07 nor the Imisngalor umich will be. 2. Balenke • Treatment groups Only diyjes gre comes oue similan size & corutituts. in the indesverition each group 3. Simplinty) easy fox to implement Simple Types Block stralijced 1. Simple Adapte Coin tossing Sogheme g RN Jnom statistical textbook Computer generated sequence & equat Con gine. no il speryul २० gups Tossing Heade: TA Tails TB •Usually done using Schedule | compilenced a randoni zakon. bo. RN generator eg: Flipping a coim Shryfled deeg Cards Thrsing a due All henu Somme Cancer typer - Conces sev. Populh New camcon treatest Follup. Mearme ontion Stel cances thatmt impalance in haselingaclones No. 9 subjects augned to each gp. 2-Block Romdomine subjects into groups that reinte equal Ss in the armu. Somple keep sne geach gp similas ores entre study Disadvantage:- equal delibut in temi I nos, not balemed boveline chonacteristics. 1 eg: Block 1- 4 subject Inom Rural area. B 2 - 4 B 3 - 3 nom Urbom, I Imon sund •11 open label.tual, segheme Somenhet predicthithe beveme eg: 2n=4 BAB next A. AA next 13 13 3. Stratjied. BR mom bock čin block. g: Age grp., <40, 41-60, 760. eg: Sex MF eg: To aiune babmu on hautne jackons Create shates septup separate randomization Schechile cin each stratum. eg: To prevent Study, isi reach the strades romdomize in <50yns, each stratum seperately. Blocking should alio be wwed within each stralium 3. Response adaptrie sondo smiration Stant i equal romdomization Followed by interim amalysis Alone allocation to titment ams that as pjectiu Unequal randomization; Allorethy equel too -g pt to expt & contul grp. -most statitically fint, maximie statistul pomer •This is hot comminal - ethically / practically feasible Suilantial costiarring - adopting smaller randin ratio 2:1 • It is coonormal to rondomine James it to expenuis treatment & more to the cheaper one.