Lecture Note About Meningioma | Coventry University - Edubirdie

University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

41

Pages:

2
Author:

Badusha S.

MENINGIOMAS Benign intracranial tumours that arive from Meningothelial Cells of arachnoid mathe/1. Aye: 20% 10 Intracranial neoplasms Molecular genetics High grade-meningomas// Loss of chromosome 22 Deletion of region of 22912 contain NF2 gene In sporadic meningiomas - 50-60.7 has mutationc in NF2 gene1112 MORPHOLOGY Sile:- And where in the intracranial site botn on surface or within ventricular system //... ext. Cornmon site porasaggital repims → CH. ol fact grooke • External surface well-circumscribed, smouth, Rounded, Bosselated poly poid id mases. Size) Variable consistency Range from Firm and fibrous ba grits (presence of psammoma bodies) o Cut surface Gray without necrosis or Hemorrhage. o Base: Att to dira. comprese but no infiltrate / MICROSCOPY whorled pattern of arr. of meningothelial cells & presence of prammoma bodies (Laminater Spherical Calcospherites Appice (11/1) Localf, aggressive tumor with High rocurrence than meningome/ •Show four or more Mitoses /10 High power field 3 Features (Increased cellularit t small cells N C Ratio + prominent nucleoli/ necrosis Anaplasti Micas agresine tumour, app like high grade sarcome Clinical Features slow-growing turmours. Produce symptoms by Lompressing brain tissue & depend on the sile Psammoma bodies. - Cont-calcified bodies. deposit-7 [concentric calcium deposit- dyshophic calcification

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