University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

69

Pages:

2
Author:

Badusha S.

Benign Prostatic Hyperplasia (5mkB) Def prostate Hyperplasia of both STROMAL & epithelial cells. Form discrete Nedules in the periurethral region of prostate // coat does it → Nodiles become large, compress & Norrow the urethral canal and cause complete or partial obstruction of the urethra & urinary outflow decreased death Rate of Call death stromal cell ↓ ↑↑ Proliferation ↑↑ Epithelial cell PATHOGENESIS OF BPH Testosterone Stromal cell (T) Epitridid cell 5--Reductase PHT reception DHT Nocl AR NUCLEUS Bondage Growth Factors Growth Factor APOPTOSIS of epithelial Celle # Androgens Icellular proliferation (-) cell death // GROSS weight - 60-100g Site Submucosa of the proximal urethra (transition zone) Site Subro Invokes both lateral lobes of prostate Cutsectioning multiple circumscribed nodules without any true capsule. GLAND + Nodule with pre-dominant (gland Yellow. pink STROMA 11 with Fibromuscl Stroma Honeycomb ked Soft-consisting Fluid-007ed pale -grey, Firm/tough Consistency. Do not exudate NODULARITY Composition of Nodules. "Papillary structure" propel ~* enter glands/ Epithelial cells Glands are lines I mo cells Outer basal log of cuboidal flattened epithelium. Innertall colouring Smooth muscle cell Stromal fibroblast. Ingersen und freq Diff in urination Urine Retention // COMPLICATIONS (Microscop Fibromusculer Stroma proliferate Blands lined by two layers of cells papillary structures project int glandular Lumes Corpora place a (eosinophilic I amin rated) concretions Strabeculatin of blador wall 1 Hypertrops of the bladder:- (Retention) Cystin's inability to empty the bladder. Pyelonephritis (4) Diverticula 2 3) Hydronephrosis (Prolog sev obstruction with Back Pressure Pressure)