University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

92

Pages:

2
Author:

Badusha S.

TESTICULAR TUMOURS GERM-CELL TUMOUR SEX-CORD STROMAL TUMOURS Mixed grill Tumor Leydig Sertoli Seminomatous Nom-seminomatous tumours tumours Embryonal Seminoma MC -Spermatocytic saminome carcinome Yolk-sac Anaplastic seminarna - Choriocarcinome Teratome Mature Immature -Teratoma with Somatii ty Re malignancy. infont & children upto 3 yos: Yolk-sae Tumour Pre-pubertal children Teratoms >Goyos-Lymphome. 1°(seminome) Bilater al 20 (Lymphoma) Risk Factors (10-1) Cryptorchidism -Klinefeller syndrome. -isochromosome [112P] gain of add fraget short orm of chromosome -Oct 3/4 NANOG Precursor lesions. • Intra tubular germ cell neoplasia (IT GCN) is a precursor lesion for all Testicular tumours, except teratoma & sperma to continental placental alkaline Phosplah (PLAP) + CF Painless enlargement Pora aortic Lymph node enlargement Hematogenous spread will inusive lungs. BOWEN'S DISEASE ✓ Both Male & Female over age of 35 yos. Male it involves skin of shaft of penis & scrotum. MORPHOLOGY Gross:- appears as single, thickened, gray-white & opaque plaque Microscop -Epidermis shows proliferation with numerous mitoses - cells are dysplastic containing large hyperchromatic nuclei & are loss of poloris - Basement membrane is intact, sharp demarcatio of dermal-epidermal border. Progression mas progres to maitrat. squamous cell carcinome //. 100% (SC) ass. with visceral cancer (CA colon or Breast) BOWENOID PAPULOSIS Sexuals active, Lesions are multiple, reddish-Brown papular 12 sions. Sites glans & shaft of penis perineal & vulvar areas Fate: Spontaneous resolution sponatar regression very rarely squamous cell carcinoma Erythroplasia of Queyrat Cesion of Bowel disease on olans penis.