University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

134

Pages:

2
Author:

Badusha S.

(Most comma SEMINOMA adysaorminame/ genetic Alterations Isochronous 12p Express OCT 3/4 and NANOG Mutatia in FIT (25% of Tumon) KIT amplification & KIT overexpression // MORPHOLOGY Grossing bulky, solid, rubbery firm// Enlarged upte ten omes of normal pestis Cut surface→ Homogenous, grey-white, Lobulated Tunica albuginea is not penetrated. Spread to scrotal sacs, epidemic, etc.!! MICROSCOPY Pattern: sheets/Cordwests of a uniform population of sepninorna cells 2. Classic sevminama Cell the constant population of cells that resemble Spermatoginia Spermatogonk cells. Cy to plan Cellare large, round to polyhedral have distinct cell-membrane • Cytoplasm pale & eosinophilic. of Watery. variable amounts of Lipids & glycogen. Nucleus • Nucleus Lorge, control nucleus with one or more prominent nucleoli / Three Strome Seminoma cells divide Mito's poorly demarcated R lobules by delicate fibrous septal Lomplen. Mephisto Positive for PLAP 2 OCT4 3 KIT Plasma cells Prognosis - Best Ratiosensitive. Localized - Metazes into graph node. -Hematogenous spread (late). Anaplastic Seminoma Cellular Nuclear pleomorphism) tumour giant cell cells & with more frequent men (mitotic figures. Spermatocytic seminoma. uncommon, 65 yrs of age, low growing Rangers Meta Staeiz, Prognosis excellent: Gross Pals-gray, C-5= mucoid east Microscope Ismally-boathook Lille cells Thin rim of eosinophilia (cytoplasm two spermatocytes/ medium-sized intermediate cells. eosinophilic cytoplasm Rounded nucleus Lorge-giant shaped cells Contract: Dlack of Lymphoglic infiltratia 2) Do not metasta zien 3) hot ass with germ cell-neoplasia NON-SEMINOMA TOUS GERM CELL TUMOUR Extareas H+N EMBRYONAL CARCINOMA: More aggressive than seminomas. MIE-Cloroph + Syncibiotrophle No ville Bich sensitive // Ostais is small, cls- vorig ted appearance, and pours demarcated. areas of Hemorry or necrosis -common/ Extends into tunica albuginea, depicting or spermatia wholly microscope Pattern lavender or tubule or papis patterns based on situated nuclei & apical cytoplasm Tumour cells appearance & Large Lepithelial catts Anaplastic -cell-border-indistinct Hyperchromatic nevelli& prominent nucleoli Mitotic figures & giant cells frequent cy to keratin (+) CD30