Tumors of Breast

Cascinoma of Breast:- Risk factoo Age - Ingcreasing Age life time Exposull ToTestrogen - Nalliparity, late first pregn (3548) - Absence of brasl feeday - Exogenous hormone tulopy Genetic wheritance Eally menasche (112) det e minalche (2556 trough amily history >ist degree relative Enviromedal - organo chloine life style - Radialion Alcohol Physical inactivity - port menopausal obsetity Types ER & HER2 1) Lukhinal cancer 1005 B Hey proliferation Y HER 2 ER + HER 2 Pearlr lates respond HER 244 ER+/- HER 2 oves Expression 3) Triple Negulive cances cancel ER- Plateau widdie HERZ- age PR- Pathogenesis Genelic ->Mutalions - Drives mutalio BRCA I Inherited Acquired have imp funch in repair of ds DNA breaks BRCA2 -"guardian of the genome". TP53 - An smp negative regulator of the pro-growth PI3K-AKY pathway PTEN - promotes cell proliferation & opposes Apoptosis HER2 BRCA1 ->Responsible for 80-90%. Single gene breast conced ->markedly i ovasion Carcinoma -20-401 → poorly deffelelal -fall in TWBC Hormond Estrogen-(TGFX, POGF, FOSE BRCA-2 -10-2011. oistics ovastar assocated with male boeff cances More often ER+ thay BRCAI - poorly diffdalides stovulates the prolifciatis 3 breast epithelial cells dusing puberty menstel cycle & pregnancy Enviromerlal Drives pro 14 felation duting the development of conces from precursor lessons Imuind type - life style modification - Radiation Exposely to peleas حمد Non Sinvalive is Ductal carcinoma in situ 2) Lobulas cascinoma tusitu invasive 1) Invasive duetal catonoma-70-80% 2) Invasive cobas calcinoma 10-15% 3) Calcinoma with medullary seatell-544 y mucinous cascinoma -5% Tubulas calcinomad * Paget's disease of the Rare ductal carcinoma - cithes in sito or invasive Morphology Gross - strim of the nipple & welkola shows ulcedalion with Dozing resembling eczenia pruestes inflammatory shay Com Carcinoma (insi - 149 Underlyning ductal croscopy. vage استد Skin in the nipple shows cluster of malignant cell the Pagets (ell in the epidednes Faget cell cell can be detected by nipple biopsy or cytological examination of the exudate Paget cells all large spherical cells with cleas cytopla & hyperchromatiy nucle sepresent Extension of deustal carucinoma via lactes due ochemistry Immuno - poorly differentialios - ERE) çovelexpress HER clinical presentation -Unilateral erythematous eruption pruritus is common & the lession may be mislation for eczema. Palpable mass-50-60%. Invasive calcinoma Majority of women without apalpable mass have only DCIS Couctal carcinoma In situ axillaly - intelad Fibroadenoma of treast •MC benign tumor of the female breast Age 20-3038 -origin-Intralobulas stroma -Conical presentation - palpable & Areely Movable mats Morphology - Sporoadenoma çom be single or multiple & unsialelal coll •Spherical nodules Movable & are usually well-documscribed foreld Grass -The tomat is not compress the suis con ding brecht bel , but fired called breast mouse Rubbely, glidening graysch white nodulls theal often size ecros Copy if duct litil structull - vextulla Duct lite & ferrous CT - Duct may be round, elongated & branching Epithelium living the duct ranges from the double kayes epithelium of normal lobules > hyperplasi a - 2) Fibrous Ст stroma constantes most of tumor - Stroma is delicate, celulas, oftch myxoid & resembles normal intralobulas Stroma - classes cation Pelicanaliculas Regulas, Round or oval glandul w - configuration of gland is iaitained Epithelius form duet with patent lumen beroz the seulsounding stroma proliferates countesen tilly alond then 2) Intraconaliculas. -CT Nevitjate invaginate into Meglardly spaces so that it appcast to be within Man Hormonal induced range 1) Epithelson - buling preguany, fibroadenom growrapidly - -I due to beentation changes I stomal - After menopause the stroma become More fibrous & densely nyalinized - Calcify & foom large lobulated (popcoon) calcification Morphologic vacate fibroadenoma Tubular adenoma-wellciromscribed tumor composedon closely paclied tubules with very scolity stroma adenoma if an adenoma is composed of acns, Y Lactating with secretory activity, seen du Pregnany & lactation uncommon vasialt lages (10cm), rapidly growing 3) Juvenile fibroadenoma - - aldos cend gir -