Cervical Carcinoma

Carcinoma of cervis Resin facter -HPV 2) Environmental factor SHPV -sexually transmitted uperson - -↑ incidence of cancel of cervix i) multiple sexual partned 2) first intercourse at young age 3) Male pallud having multiple sexual pallonels 4) persistent infection Ex: HPV 16 & HPV 18 5) Immmune immune respond inefficiend -Classification Allow oncogeritc -Cause condyloma acuminatus in vulva -HPV gerome is maintained in a non-integrated free Extrachromosomal form -virus free replicate & cause death of holt cell & it is known as productive ufletion 3) High Oncogenic - HPV 16 & HPV 18 - MC cause can also caus cervical calcinoma y SCC of Vagina, Vulva, Anus, pomis & tonsil & oropharynx. integration unto hose dupi - which is impfos Maliquant theus formation Integration causes -oves expression of the oncoprotein Ef -Genomic in slability into the host cell - features Even thongs HPV is a cousative factor, only Sew ufected develop courcel med dead it my urmel - morl women. realton -Longer the dus altor of ofector higher the 879. of arces inyent with High Oncogenic virus sell longes that lafgot Low HPV immaturl boral cell of seuamous epitition of muratule metapedic squamous cell at squamo - Intect only demaged surface epithelin. E not matin, Howens these matull cell progress through y emen nyected with HPV by using hard cell DND Replication occurs in mature proliferating Squamous cell which noumally arested in upus Synthesis machinchy to replicate its own genome HPV has to induce ONA synthesis & must reactival. the milotic cyve in such nonproliferating cells - Viral replication results in cytopathic espet Oncogenesis of HPV High risk - E6 inhibit p53 leads to cellul ummortalization Inhibit RB & inhibit Cyclic dependent e this is bection Aprogle cell cycle & inpais asel thy of cells to repail OVA integration of viral DNA into kert genome 1) Expression of E६ ६ Y dysegulation of oncogenes new the site of vita ursestion - Exchronosoural typeof viral OND -Environmental factor I Hobsonal chayls y oral contraceptives 3) presence of co-collinogers 7) bietaly defidency 5) Co-Existing microbial usedon * Invasive defalcinoma of cerupt HSIL is an immediate prelussor of cervical Squamonl o precursor lession of adenocarcinomal -Age-140-60-cervical cancel Morphology Grass Fungalting (sxophylac) - Nocdubad, exoplytic cauliflower lille growth protruding into vagin IDF Jullerative lesson-leclated, granulas, cloded 3) Inpy Hrative mass -Barelled shaped cervix -haldering of cervix - tumos ated in endo cervical canal Microscopy DSCC-80%. MC - Solrd nell, groups of Malignant Squamous cells (eithe! Kelatinizing or nom I large ceu Kelatine zing maling rundeslyngstoon. 6 of Kedalinizing - nost a rehatinised cell which form concentric whorl Known at Kelales peall S Large cell won regatimizing - Shaus nest of large valigat SC Sheathy individual cet Kelatini zingloul without any B) Adenocarcinoma (1540) Kelatin pearls - Malignant endocelvical cells forming glandulas Pallely -Tomas ceils all lage, hypeldironation I Aderosquamous calcinoma -rall Maliquant glandellas epithelium d) Neuloendocrine cervical carcinoma - sentlasto Suwall cell sa of leng Spread is Hematogenous - lines, lung & BM Lymphalic - pala celvical, hypogastric External iliac nodes s' 3) Direct - Susrounding tissue & rogas palaceluscol tish of y UB Erectal 31 wittess CF 41 vagina -vaginal bleeding -Advanced uues Screening Pap smel Colposcopic examination radiationg