Tumors of Male Genital Tract

*Testiculous Tomor Divided 2 magor calegories II Germ cell tomor -208/% A) Germ cell tumor from geam cell neoplasia in situ 1) Non-invasive germ cell neoplasy a 2) in-si (GCNIS) Germ call neoplasia Tumors of thee a single histological type (Pule forms) -Seminoma 3) Non-seminomatous germ coll tumor - Embryonal carcinoma. Telatoma, postpubeltal type - Yolk Sac tumor port pubellal typ Trophoblastic tumor, 4) Non-Semino matous germ cell tumor of more than I histological type - Mixed call tamo os polyacubryoma diffuse embryoma B) Grey cell tumor unrelated to gesum cal Neoplasia insite Terotoma, pre puboltal tural Spelmato cylic tumas -Mixed telatoma Volk sac tumor, pre pubellal tumor - II) sex cord-stromal tumor -20% A) pure tomor - Seltoll cell tumor, lyding cell tumos, 14) mixed & unclassified sex cord stromal tumor #seminoma - Maligrant Gery call tuner -Most common type of gets cell tumor -50% GLT Age- 30d decade (30-4078] -neves found in import & prepubeltal children -ferrale counterpell - dysgerminoma - Orican - Classical surinoma afises from. unliffes entrated gesur cell -594 Genetic Altelation → Seminomal contains as isochromsome1zp and express OCT 314 and NANOG → mutation of KIT Concogenes) in aboud 25% of humay IKIT Ampifcalios & ovel expression very also occuls without gantic defend Morphology Gros Bulky, said, rubbery-ffom & bosselaled tumors. -2-6 can telles is enlarged, lox cutsusfact - homogeneous, gray whil lobulated - Tum06 is chadply demal Coated from normal telfer, which may compressed & atrop c -Tunica albuginia is not pencetoaled Area of nechodisas wemorrhage wot scen spread -Local spread -Spread to Gate tertis -Invasion of the epichydynes Ly mpalte spread prognosis Abd LN - Extranchy radio sessive - Remain localized to tells - metastases manly involve LN moscopy -It appels morphological strical to Candysgesudnoma ofovaly I Patlely cord of uniform population of seminoma cely. y Seminoma cels -uniform single population calls resemble spermatogonia -Celly all calge, round to pobytaled -cytoplasm-pale- eosinophille Nucleus-polygonal with fomely gramul ed aromatin -mitoses valy in numbel 3) Hama-cous deved ed into Poorly demascaled boches 4) Rale feallll Syndyliotrophoblalt (151) >imal sjimmunohistochemistry -KIT OCT14 & SALL4 + Invasion of the telliculas palendijuma Hematogenous -Ho spocad occus calle -Bell progrdis Tumor markeds IProstale - Specific Ag (PSA) Mallimp rumor malhes used for diagnosis & Managarat - PSA is seline protease produced by prortale secoty celes inthe prostatic ducts &acinic. And only" monale aunt of PSA Granate in the schun (ungmit> is a cut off poiul bw Ne Ablohal serum lend strongly cosselales with risk of Prostate cances --↑ blood PSA level occurs with localized as well as advanced prostatic cancel be normal of less But RSA level may PSA is organ specific not cancel specific limitation becouz PSA ↑ in benign hyperplasia, prostatitis & with mechanical manipulation of ros - Seleum PSA is used for screening, for diagnosti, therapeutic & progrollic puspase -Selial management of PSA id are weesul for aksesling the response of therapy EX↑ PSA oftel radical prostatectomy indicates recuss auce or dissemination. Proslate-specific Antigen derivatives - PSA deusin kalio blw seluy PSAE, VOl of pr -PSA velodly rate of change in PSA value with Age specific referance Gauge Ratio of fore & bound PSA is Serum prosledic Acid phosphate se created u prostatic epithelium, 1000 xgreafel es prostale than any ones terpop - I inprostatic courel has spread beyond proslall - Not prostale specithe increase in bone valiguany, revel Boweno'd papulosis - Bower's diseasl -sexually active adult youngel age - multiple lession, reddish brown papalaly lession - Sate 1 lesso Tendency towards spoutaneous resolution y spontaneous gendation regression 3V very sallly invasive scc