University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

277

Pages:

3
Author:

Badusha S.

Basal cell Carcinoma -MC, slowgrowing, invasive - cances that rarely nelastan @ccuss at sun exposed bite & in fail Skinned people ywall site is above line drawn from aghe of wronty & cal pinna -origin- BCC derives its name from the cytological simillall of the tumor cells to the normal basal cells of the epidermis Pathogenesis -more common in paliel with immunosuppression& inhesited defects in DNA repais such as xerodedma pigmentosum Geretics is Mutation in tumor suppressorgene "Mutalion MPTCH: PTCN all as thmor suppressa gene that negalekgly regulated Hedgehog signaling -'oss of Suction mutations in PICH cause of legoly to constitutive relivalion of Hedgelsog ratwas - this in tuly active many downstoer geme involved in cell prolifelalion & survival mulalio of gemes belonging Pathway all ip for that. to PICH signalny the development. of boty common sporadic & ambettled fiom, of Ble sporadic form - PICH mutation found in 30% E may be due to uv o Germline mutation "Nevod basal (c Syndrome Gorlimsyndrome 1953 mutalion -It is an culto somal dominas -UV 19egdet common is boty faurilial: E sporadic BCC 2) Defect in DNA repais geme-xeloderma pigmentasom increased sincidence of BCC EC - Peally papules, dilated subepidermal Blood vessels Some humor contain Melanin - & may resemble vmeleroma Adele tumor very ulcesale glocally invade, erode the underlying bone or facial sinused litre codent & all known as sodent velles Morphology Gross - Nodular, ulcerative, superficial or clytunators Spredent as module that -Nodulo- ulcerative BCC MC y Ecades underlying tisseur 20 & undergo calailukelat →Typical lession consist of slowly entalping wees Sutiounded by a peory, rolled bordes Jeremyesso-called rodent calces A Microscopy- Tumor cells- Resembles normal basal layed Same as basloma -Tumor cells deeply basophilic epithpipal ell Arrangement que a large, ovalor clangotednuncias with nallow sis of cytoplasm -Tumor cells all allangeder nell and alla red to cridem's & Profunde it papillal y deusis. •Peripheral palisading at the pheliphery of each nore columnal cells all arranged badially with theis longaxes in parallel algumort known of Palisading ciefting itifaelblw tomor islands adjacent stromy help to distingusty biw BCC from other Adnexal •2 Palley of growth - multifocal -originate from epidedures & Extend to skin surface -Nodulal lesions - goowdeeply doos wasg into the delux with hypes chromatic nuclei