University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

50

Pages:

2
Author:

Badusha S.

SKIN-SCC Ind 2 most common tumor alising on sun Exposed - sex men sfemale -CF-shas bly defined, red, scaling plaque Risk factor - uv light - May produce DNA damage & Extremely high mutation load MC cause of of SCC -Risk & degree of life time sun exposuk chronic immuno suppression due to sgan transplantation ०४ - chemotherapy sunlight can cause a defect in cutarous immunity by deducing the immune survilence function of epidermal Langerhans cell -othes risk factor → old born scars (Margolin's ulcer) -> Industrial calcinogen (Tals&,015) -Schronic non healing ulcer -chronic osteomyelitis ->IR → Tobacco & bettel nul chewing in the oral cavity Genetics -Mutations in tumor suppresor (TPS3) ov light damage DNA, SCC induced by sublight TP53 mutation occass as cally puert cells with DNA damage ase alselted in G, phall -> DNA may under go repail, or Apoptosis of it is demaged beyond repal mutation of TP53 Sunctions result in loss of protective nutalion of DNA Repais geme-xesoddma pigmentosum is a disordes chasadelized by inherited DNA Repues gerre this paliat susceptible to SCC Morphology Insitu scc scenes csith atyrttal nucle? involving all levely epidermis cons way as rough basement membrane Invasive sc Gross -Invasion lessions ase more - which advanced lession appeals as modulal growth & may ulcerale Ukes surrounded by wide, elevated, indul aled borde Microscopy -Tumor consises essegulal mass of epidermal cells thal proliferale down wards into the desmis -Variable level of dyferentiation 1 ) well-differentiated SSC - Produce large can't of kelalin polygonal Squamous tomor cells allanged. mordellylobus -Some of kelalin from epithelial & care characteristicaly ⅱ) Modesaley scc - single cell Kelatinization Anaplastic squamous cell Associated with geographical Necrosis iii) poorly differential sec high Anaplastic ceu - poorly dibe requise iussunohistochemical. stailfor