University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

370

Pages:

2
Author:

Badusha S.

well's disease Leptospirosis 2 Species 1) L. intelsogans. L. biflexa Pathogenesis -It is a zoonotic disease Mat can cause hines kidney damage, meningitis, Rschistress seven datti MOT-Zoonotic dised H-H does not occurs Indirect contact- moise soil, wales, wet sulface contaminated with animator rrect contact with urine - Rats, dogs, cattle pig Source - Seosondity - Rainy season of monson pestols -Risk factor - lowed social economic status - Urban & rulal shur abla - Ranfall & floode - occupational Expolisl Two distinct plases Ist phase (septicente phase) -Afted entering through mucow of atraded skin L. intel royons spills over the blood stream & they dissentmatt hemotogenously to various organ meloding brain, orain, long, long, how hot & Midu cy • Valculas deurage - spirocytes can be found in walls of capillatiel, nedion & large sized estel o penetration & invasion of tissue is due to motell nidade & Gelease 240 (immune Phase) 25 - As As develops spirocheles disappects -Ab complex deposited in various organ Ag-Rb "Renal colonzallas Baccili become - adhchend to proximal renal hibulas Lous, besiedels we CM p-10 (1-30de 1) Miled amictelse febrire illness -90% fraliend -139phasic -septicemic phase access first followed by imмоне - flu 10k sellers, leves chils, Lieadache conduchiel suffuego, N., and pom & myalgia 2/weil's disend -Typical (Hepato-remal illness 11000 vemos hagic synde) way hot poredad Ipion Progresal LAB dugross -Specimens blood, SF, line -MPCroscopy-spirally colled bacilli, hooked ends like umbrella handle - Isolation - • cultull condilion- 302 80 4-6 weer Medion - EMJH medium, Korthofls - Animal inoculation - Samples inoculated into handless & - - Selology ELISA, ICT - latex agglutination -Moleallar methods. PCK-235 ORNA - Non specific finding altered RFTE LFT