University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

473

Pages:

2
Author:

Badusha S.

1) Naegleria fowleria -cyst trophozoites form #Trophozoites -2 form Amoeboid -found in hurar. Flagellated Amoeboid form when subject to bistalled wald flagellate form * cyst -Thicth smooth double wall found in environment Life cycle & pathogenicity - Infective Loom - Amoeboid -MOT- Nasal Contamination duling sushimiing in fresh Mot wald bodies like pond rive laties - Rasely if the Hagellated or cyet hom enters it will revelt to amebord - CNS an valion - Amoeboid form invades the nasal & travel to dlong the olfactory mucosa nave to reach bram - The penetration mittaly results in nasal nearosis & olfactory bulbs A Tissue destruction- 2 mechanism > Direct Ingestion of the brain tiskups by produc food cups 2s conotact dependent cytolysis Free living Death anoeboid Hirpotolled in walco menigoencephalitos Human infection by in hal penetration of nerve infection Bimary Meningowcephaletes -N. Powleli cou cause acute supaliative fulminant - infection of CNS known as PAM It is named so to differ it from 20 MC in children. IP 1-2 days-zweelis - dinical course acule & fulminant initial Symptom charge taste & Surell due to olfactory neve followed by demaye H, V, Anorexia, N, high fuel & sign of meringical involument like stoff neck sa tue kenig's sign - 20 symptom-hallucination, loss of attention seizues Mestality -981. LAB -CSF specimen - - unmediate - CSF Analysis thielt purulead with pus cells > 20,000/ML (protein) minic bactella mchingites Microscopy - chalatelists of the Trophozoiles confirm thel diaghasis cyst not seen wet mount - Mople anoeboid trophozoites - Histopathology- Brain biopsiedtescue - culture-No-Nutrient agas -Enflagellation test scrapping of the hon - Iso enzyme analysis nutrient agas - Molecules methods multiplex realtime PCR - CT Scam & MRI Treatment - Amphotelin B