University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

241

Pages:

2
Author:

Badusha S.

Rickettsia infection. 2 group Typhus group il) spotted fevel group Anlagenic structure cen wall of rickettsia is similes to groutere bacteria [peptidoglycans, lipopolysacchased outely membou -OMP ase Species specific thus can be used protein naglily immunogenic for vaccine -LPS - group specific - 99 cal test used. Sesological for dieg Pathogenesis -Transmission- Frll rickettsia are transmitted hur by Arthropod vector -Transmission by bile os seratering, rubbing on abraded skin of mucosa - Tick & mite can act as resesvious - Spread through lymphatics from paltalenty -multiply in regional lymph node -Then spread via blood stream -Spread -Target site - Endothelial cel -Phagocytosis-Adhesion to endothelial cell by omp -OMPAS OMPB present of rickettsial sullal -following adhesion, the organs'sing all Phagocy toled Intracellulas survival Beings bisgate intracellular - following phagocytosis they survive insid the host by following archanism. I lysosomal 19lling ii) inhibiting phagolysosomal fusion Inside host they multiply slowly by multiplication -cell-to-cell spread Linaly Assion spotted feres com spread cell to cell byal, polymesisation - J Epidemic Typhus -> R. prowa zelal -vector -House hel Human body acquise louse, pediculus humans copos the orgenen while talking boos meal from an infected posson -MOT scracthing -Rubbing s -com-Acute febrile disease & uhalation of rousel fece Mlab • H, myalgia, eye dil charge & saghed of th Ip 1-404 2) Endemic typhus (Flea boomp] LR. typhi Ve dor-Ral flea MOT - Rubbing scracking inhalalion Res esvoir - Rodent such as Rattus CM-IP 1-2 weeks -feves, nyalgia, headache, rash & anorexia oreographical distribution - South cast alla Ewerter India pacific 3) Indian Tick typhus -> R. conorii vector tick CM - RMS fenyes - eschas -at the state of tick bite -50% cales Disease is more severe in patient with Dom, Alk Geographical distoubution-Europe, Africa, India spoted 4) Rocity moustain févet - R. sicketist? Transmition- Tick Reservoir - Tick sche os vector & reservoir CM-IP-4-14 day - RMS fevel -fever, headach, rash, myalgia & anorexia on Extremities Macalopapulas lates hemorras complication - Vasculas damage, I permiability, edema, hamorrhage Geographical - USA, central & souts Amedical Moll in children & Meц LAB -> schological Ab delection weil-felix tert - in epidonic çendemic typhus ToX19 Ab -Tick borne spoHed fever - 10X19&TOX2Ab - In scrub typhus → Histological Examination - collection biopsysample ELISA →Isolation-by inoculation cell line -PCR