Lecture Note About Urethritis

URETHRITIS GONO COCCAL URETHRITIS- -Neisseria gonorrhea is non capsulated gran negalive Kidney shaped diplococcus - STI commonly manifelld as cervicitis, Urethritis, & conjunctivitis virulence factors - Pilli or fombrial - Adresion to hostcell & preveal baddia from phagocytosis - oules Member proteins Porin (protein 1) - more than 50% of total outes. Membrane protein. •My forer trasmembrane channels which helps. in exchange of molecules across gonococcal surface • opacity associated (Protein II) - helps adhesion to neutrophils & other gono cocci Clinical Manifestation -in males Acute urethritis is the most common. pufuled urethral discharge. - -IP 2-7 days •Untreated cases may go for complication Epididymites, prostatitis & balanitis - Infedion com spread through to peliorethoul fissey causing abscess & Sinus formaban - females less severe More assymptomatic calliage Mom males. 1) Mucopurulent cesus (9.19s -MC, crasaddized 2 by scarly vaginal dischar ) vulvovagnilis- Not seen Adult female as adult vagina is resistant to gonococcal felfon - it can occur in prepubertal gids & polo menopausal women can spread to Ball tholin's •Spread-ufection gland, endometrium & fallopian tube ・Fitz-or-curler cyndoond rall complically crasaelelized by peritonilis e- - In both sex - Anoredal gonorrhea (spread by and & usually mullidovy registe - pharyngeal gonorrhea ispread. orogenital sex by - oculas gonorrhea - In pregnent women rupture of membrane premature delivery - In neonates Copthabria pululent neonato com) -eye dischaly -2-5 days of birty - In HIV-infected pessous - Noy ulcelative gonorrea enchaces 5 folds spread of IN infection possible bear of incocared viral shedding LAB is specimen collection -urethral swab & cervical swab inmen vagial Swaمن ط mwomen net Salifactory 2/ Transport Media - Transported immediately if not possible, they it should cchalcoal coated 3) Microscopy Gabon stairing of cesetsal Excida reveals grouss wegalive intracellul Hidney shaped diplococci 4) culture Endocervical culture has so 5) Ideals ficatio - Cronoccoli & catalase & oxidall to -ley only present glucoll butnot 6) Morental -PCR maltose & sucooll - MALO Maltos Treatment- Doc 3d NAR TS guests cephalosporin promybags - No vaccine Early detecten -Treall both partners Non Gonococcal infection (NGU) →Chronic urethritis well gonococd cannot be demonstrated CHLAMYDIA TRACHOMATIS INFECTIONS Ahlamydiac are Boelelia, Not viruses vival properties obligate utracellular - cannot be grown in Al media - produce intracytoplasmic inclusion Now it comfirmed that hulamydia is bacteria propellices Posses Boty DNA ERNA - call wall is sinplal to gran Negative Bactodia - Multiple by binaly fusion -Susceptible to a wide range of antibacterial agents Life cyde:- -2 distinct morphology forms - elementary body [E and reliculate (RB) - EBs all the Extracellulas & infective forms attach to the specific receptors on the host cells EBRB: following entry they trasform into reticulate bodies which all the intracellulal for -survive beide the cells by prevaling plagolome Igsosome fusion. -RBs are replicative foron: divide by binary Passion they ale also the metabolicaly active form E con seuthesize the's own Nucles acid, lipidl Proteins Palalties excepts ATP : hence alled and - RBS present inside the vacuole may enlarge to forum indusion bodied, that can bertadily dele led by histo Hogical stany RIBS EBS which are subsequently relased from the host ccel's by be hous Genital infection (citrachomatis) * Non gonococcal urethritis (NGO) - MC Came 30-50% iffers from gonococcal wethritis -onset (7-10 days-Ip) of symptons - symptom - Macopurulent discharge, followell by dysuria, & Urinaly trad uраt * Porl yonno coccal urethritis C. trachomatis u MC - urethritis develop imman 2-3 weeks fles rcovery from GU -This occurs when GO is treadedeith Penicillin or cephalosporin alove withouladdy Auli ciplamydial diery (Azitromycin) * Epididymitis in male - C. trachomatis (we A Reactive arthritis - Int consists of consuntivites Urethrilis, celvicts, allturiis chasacterizedy muco cutaneous lesion -1-21 of cases of NGU, develop 1-4 wealt after genitalefation - Mens women (00:1) -Mc Cause of phelipheral inflammatoryal tesi -Knee, antle, small goals & Salsol/9ac goste A In femall all commonly ofbeled -Muco pulerlent celvicits (MC) Endometrilis, salpingitis pio. - Perinepalitis LAB specimen -sepends upon the types of lession 2)1900sxopy - peteds chlamydial inclusson bodies Gran String bigael It of Auflady defedin 3) Antigen dete clonmuroassay ELISA -goll Slendard in worl Egg Yolk, ceuling. - 5) NAAT Maclonkey ago) -PCR Most sens pave & specific method -cusraully the diagnostic assay of hoge