University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2023
Views:

70

Pages:

5
Author:

Badusha S.

Etiology & Pathogenesis Tobacco Smoking moja Carcinogens in Jobacco seota Polycydia to aromatic by duocantins Radioactive elements & othe confinements. Strongest association of sneaking - squaman call a stall call Carcinome. 90% in smoker depends on: 4 Gmant amount of of I daily doily smoking. smiling fender to inhele 7 duration of the shoking lebit. Indentu hezards Jomising radiolos. Radon increased long cover in miners exposed to high wriantbrukare. Veronium weakly reducctve Aspertos. Others Atmospheric pollutes. dil vit A defeciony leads to sqromas huloplasia inquend susceptibility do concer. Idiopettic pulmonary hea gened predisposition gende polymorphism inuding Cyt p450 gene → incoward capacity to rubobobse procar cingens present in ögarette smoking incrwand risk of bay bnver. Molecular Genchis Squamous cell Corinan → Strongly associchel with Shoking togenete aberrations indude- - Inactivation of tenues suppeusser geme. → los of RB times suppuens Sand in 151. Aquaman Cell Carcinow. Achuchun of EGFRI & MET - Activation of Oncogenes. Amplifidon of FGFRI & MET → Mulators leng EGFR, KRAS, ERBB2) Mor Sequential steges of pathogess of bay concer Norond epithelium based all typaplora Aquamen metaplers Invasive Calcinour. Carcinoma in sites < Dysplasia Morphology gros. Sik & pattern of growth. - Peribronchid growth. Jerman appear as wened leas in de branch; the pendless will of bronches & infilterte into mediastinen Intes parenchymal granth like th. in this pattern, damos grows a coat shower the pernilga hoss which pushes surroundy Cung substome. Exophytic guanth Sitarth - - an into the linen producing an endo branchial termes projectly. intraluminal mets → as it enlarges it obstructs inadved branches leading to aklechesis & infecher. colo & casistery grey whit in ider; form to hand in the consistency of haemorrhage Cut sedes Shous faced microscopy cherastaishi Senteures an Kesutinisoles -epithelial kochin pearls. individud cell karotinjotun 4 Introcellule beudges Neuro endo carre Jumas (Anull cell carinone) → Strongest assouches with smoking & hory similar hideculer fechers of Aquamens cell carcin Irechucten of dinos suppence gun. → Los of funter buttons involwing TPS3. (75-901) RB C100% of undes - Activation of oncogene & applications of gener of MyC family Morphology Ate My Aus in major bronchi ((enkud) & in periphery porton of the lung es sechen Soff, Sewable & white, Shaw extensive memory & + hurais. Light microscopy So & stepe Small bound to freshen ool cell freund as randes less than 3 times the size of small Cymphough. poplasm scanty, Leindly stained with ill-defined cell bordes. nucleus hyperchromatic with finely granules thrombin (sall & pepper pothan) →high Mitohe count. Jumor cells grow in sheets or clustus. Electron microscopy than hauberen band hevesseirtay grimly. Regin of fumes Shell cell temos limos arises from reves endocrine pleasanter cells present liny of brouhid epithelium evidence far this: (1) presence of hoursburetory guanly (ii) spussion of neuroendocrine markers. (Chromogranin, synaptophysin, (057) (iii) Deerchen of hornunes. All small cell Arénamas agadusse buy Sumors. a high gunde & mat > widely mulostosire E incurable by surgery but sensitive to chemotherapy.