University:
Dartmouth College
Course:
BIOL 51 | Human Anatomy and Physiology
Academic year:

2023
Views:

176

Pages:

2
Author:

pennu4565

Atrophy ATROPHY 00:30 Definition : Reduction in size of organ ortissue due to decrease in cell size & number. Causes : Pathological ↓ work load) (Disuse atrophy) Eg: Fracture of bones Loss of nerve innervation (Denervation atrophy) Eg: Polio Diminished blood supply (Senile atrophy) Eg: In Brain dit old age Diminished nutrition Protein energy mal nutrition Loss of Endocrine stimulation Eg: Post menopausal women: ↓ Estrogen size of uterus Pressure atrophy ↓ size of breast Eg: Tumor compressing a organ. Mechanism: Atrophy occurs dit degradation of proteins via the UBIQUITIN PROTEOSOME PATHWAY Through this pathway misfolded or damaged protein are removed.