University:
Dartmouth College
Course:
BIOL 51 | Human Anatomy and Physiology
Academic year:

2023
Views:

430

Pages:

2
Author:

pennu4565

Reversible cell injury Occurs due to Mild non-lethal injury Irreversible Cell function Effect Biochemical change Electron microscopic Change Light microscopic Change Gross morphological Change EFFECT OF REVERSIBLE INJURY ON A CELL 04:00 Mechanism Mild non-tethal injury Mild ischaemia ( Blood supply) Mild Hypoxia ( 02 supply) ↓ATP Prod. Aerobic Glycolysis Lactic à prod. BIOCHEMICAL CHANGE KT-Na ATPase pump Nat↑ intracellular Na ATP Extracellutar fluid enters cell (Slight) Chromatin condensation [Light microscopic appear) Electron microscopic changes → Bleb formation Water enters the cell Micro villi •Microvilli on cell surface •Cytoplasmic bleb formation • Organelle swelling →ER Swelling: Ribosomal detachment Protein synthesis TQ Breaks, Free fatty acid + ATP Accumulate in cell to produce FATTY CHANGE Mitochondrial Swelling LIGHT MICROSCOPIC CHANGES -Cell Swelling : Due to movement of water inside the cell. -Pale cytoplasm Due to water inside the cell Cloud swelling (HYDROPIC CHANGE)