University:
Dartmouth College
Course:
BIOL 51 | Human Anatomy and Physiology
Academic year:

2023
Views:

439

Pages:

5
Author:

pennu4565

Intracellular accumulationLIPID DEPOSITION00:50- On H&E Stain Appear Clear Vacoule- Special stainOil Red OFresh tissueSudan Black Formalin fixed tissue-Types of Lipidsi. TriglycerideSTEATOSISCause : Alcohol abuse, ObesitySite of deposition : LiverHeartMuscleKidneyTIGERED EFFECT:- Deposition of yellow streaks ofTGS on surface of Heart grossly.ii. CholesterolSite of deposition : MacrophageSeen as: Pale coloured macrophages called FoamCells.Cause: AtherasclerosisXanthomas: Lipid deposition in a tissueCholesterolosis: Gall Bladder Neiman Pick disease: Sphingomyeliniii. Phospholipid deposit:DepositionCause : Irreversible injury > Reversible injuryalso called : Myelin figuresPROTEIN DEPOSIT07:15OnH&E Stain Appear Eosinophilic (Pink)Causes: - -Resorption dropletsProteinuria (PCT of Kidney)- Russel BodyPlasma cells in Multiple myeloma-Hyaline changeIntra or extracellular pink deposits.GLYCOGEN DEPOSITS10:50AppearOn H&E StainClear vacouleSeen in : DMGlycogen storage diseaseSpecial stain : Periodic Add Schiff (PAS)Stains the glycogen Red. CALCIFICATION12:00DystrophicMetastaticSeen inDead & DegeneratedLiving tissuestissueAlveoli of LungBM of Kidney(Due to int. alkaline environmentof these cells, Ca2+ has moreaffinity) ,=-SerumCa2+NormalRaised (Hypercalcemia)ExampleR AA THyper parathyroidismRheumatic H.DVit D toxicityAtherosclerosisMultiple myelomaTuberculosisSarcoidosisTumorsform Psammoma bodyMilk- alkali syndrome PIGMENT DEPOSITION18:10Endogenous:-LIPOFUSCHIN Lipid peroxidation product due to freeradicle injuryPerinuclear brown pigmentsinside lysosomeBrown atrophySigns of cellular ageingWear & tear pigments Melanin :Site : Hair, Skin, Iris, adrenal gland, brainSeen in : MelanomaStain : Manson FontanaIron :-Special stain : Prussian Blue /Pear StainExogenous PigmentsCarbon DepositsSite: Alveolar macrophage of Lungs-SmokersAnthracosis (Coal worker)SkinTatoo