University:
Dartmouth College
Course:
BIOL 51 | Human Anatomy and Physiology
Academic year:

2023
Views:

268

Pages:

6
Author:

pennu4565

Cellular Events of InflammationB. cellular events1. WBC movement in lumenMarginationRollingAdhesion2. WBC components across lumenDiapedesis3. WBC movement outside vesselChemotaxis.1.of2.is3.4.CD311. Margination: occurs due tor5.Stasisselectins 2. Rolling Endothelial molecules interacts with the WBCmolecules.Endothelial MoleculesWBCEndotheliumE - selectinSialyl Lewis - x- GlycoproteinEndothelium,P - SelectinSialyl lewis -X- - GlycoproteinPlateletsLeurocytesL- - selectinSialy! Lewis- x - Glycoprotein(Neutrophils,on endotheliumMonocytes,T cells)3. Adhesion.Endothelial MoleculesWBCI-CAMLFA-1, MAC-1B2 IntegrinColla/CD18CD11b/CD18V-CAMVLA- - 4 (CD49a/CD21) B2 Integrin.4.DiapedesisEndothelial MoleculesWBCCD31 (PECAM-1)CD31 (PECAM-1)PECAM : Platelet Endothelial cell Adhesion Molecule. 5. Chemotaxis :movement of WBC along a chemical gradient (chemokines)Endogenous chemokines :i) Cytokines (11-8) - (x. chemokines)ii) Csa (complement)iii) LTB4 (Arachidonic acid metabolite)leukotriene.Exogenous chemokine:i) Bacterial products (N-Formyl Methionine)Mechanism:chemokines act on G-coupled Receptor on WBCActin polymerizationMovement of WBC along chemical stimulus6. Phagocytosis6a - Recognition and attachmentRecognise self and non-self - molecules with help ofrecepts. Eg: a) Mannose-Receptor - : binds to Mannose andFucose molecules on Bacterial cellb) Scavenger- Receptor : Recognise oxidised-LDL6b. opsonization:coating of an Antigen to increase efficiency ofphagocytosis.Mediators: opsonins / opsonizenEg: C3a, C4b, C5bC-Reactive Protein (CRP)Fc-Receptor of IgGFibrinogenIgGAgFeNeutro/FabMacrophage/PhagocyteAgFc-Receptor of IgG 6C. EngulfmentPhagosomeAgAgPseudopod (pit)7. KillingPhagolysosome.fusion is broughtby gene called as LYST gene.Ag(on chromosome 1)lysosomelysosome contains Hydrolytic enzymesThis is Oxygen Independent pathway.Oxygen dependent pathway : more efficient way of killing Respiratory burst orO2NADPH oxidasecoded byoroxygen burstPhagocytic oxidasePhox gene.activityO2SODNOFe2+-H2O2FeOH]FENTON REACTION(peroxy ONDOnitrite)MPOHalide(a)HOC /ociPhagosome.H2O2- MPO - Halide system : Most efficient bactericidal systemoci- : Most efficient bactericidal agent.