University:
Lehman College
Course:
CHE 444 | Biochemistry I
Academic year:

2021
Views:

489

Pages:

19
Author:

RubyChi

Carbohydrate Metabolism MCQs Carbohydrate Metabolism (MCQs) The activity of PFK1 can be decreased by all the following except: a. ATP b. Citrate c. Glucagon d. Fructose 2,6-bisphosphate An example of Substrate Level phosphorylation is the reaction catalyzed by: a. Glucose-6-phosphate dehydrogenase b. Glyceraldehyde-3-phosphate dehydrogenase c. Pyruvate kinase d. Pyruvate dehydrogenase complex e. Pyruvate carboxylase Oxidative decarboxylation of pyruvate requires: a. Thiamine pyrophosphate (TPP) b. NADP c. Pyridoxal phosphate (PLP) d. Biotin e. Cytochrome P450 Which of the following enzymes is not involved in the citric acid (Krebs) cycle? a. Fumarase b. Isocitrate dehydrogenase c. Succinate thiokinase d. Pyruvate dehydrogenase e. Aconitase Oxidation of citrate to succinate results in the production of how many moles of high energy phosphate bonds per mole of citrate oxidized? A. 4 B. 5 C. 6 D. 7 E. 8 ___(is/are) used to maintain blood glucose level during fasting: A. Muscle glycogen B. Liver glycogen C. Both of them D. Neither of them Pyruvate dehydrogenase complex & α-ketoglutarate dehydrogenase complex require the following for their oxidative decarboxylation: A. CoA & lipoic acid B. NAD & FAD C. CoA & TPP D. CoA, TPP, NAD, FAD & lipoic acid During glycolysis, fructose 1,6-bisphosphate is decomposed by the enzyme: A. Enolase B. Fructokinase C. Aldolase D. Pyruvate kinase Actions of fructose 2,6-bisphosphate include: A. Inhibition of pyruvate dehydrogenase B. Stimulation of phosphofructokinase I C. ___ D. ___ E. Inhibition of pyruvate kinase 41 The major process responsible for maintaining blood glucose 24 hrs. after the last meal is: A. Glycolysis B. Glycogenolysis C. Glycogenesis D. pentose phosphate pathway E. Gluconeogenesis 42 The activity of phosphofructokinase - 1 can be decreased by all the following except: A. ATP B. Citrate C. Glucagon D. fr. 2,6 bisphosphate 43 An example of substrate-level phosphorylation is the reaction catalyzed by: A. Gl. 6. phosphate dehydrogenase B. Glyceraldehyde 3. phosphate dehydrogenase C. pyruvate kinase D. dehydrogenase complex E. Carboxylase 44 In muscle glycogenolysis, converting one glucosyl residue in glycogen to two molecules of lactate, what is the net ATP given? A. one B. two C. three D. four E. Five F. Six 45 A high energy phosphate among the following is: A. Glucose-6-phosphate B. Glucose-1. phosphate C. 1,3 Bisphosphoglycerate D. All of these. 46 Conversion of pyruvate into acetyl CoA is catalyzed by A. pyruvate dehydrogenase B. Dihydrolipoyl acetyl transferase C. Dihydrolipoyl dehydrogenase D. All the 3 acting in concert. 47 An allosteric inhibitor of pyruvate dehydrogenase is, except A. acetyl CoA B. ATP C. NADH D. Pyruvate 48 Among citric acid cycle enzyme a flavoprotein is A. malate B. Fumarase C. succinate dehydrogenase D. isocitrate dehydrogenase 49 In citric acid cycle. GDP is phosphorylated by: A. succinate dehydrogenase B. Aconitase. C. succinate thiokinase D. Fumarase. 50 Malonate is an inhibitor of A. Malate dehydrogenase B. α-ketoglutarate dehydrogenase C. Succinate dehydrogenase D. isocitrate dehydrogenase. 51 Phospho fructo kinase is allosterically inhibited by A. Fructose 1,6 bisphosphate B. lactate C. pyruvate D. Citrate. 52 All of the following are allosteric enzymes, except A. citrate synthase & α-ketoglutarate dehydrogenase B. succinate thiokinase C. succinate dehydrogenase 54 Glucose 6 phosphate is an allosteric inhibitor of A. Gluco kinase B. Hexokinase C. phospho hexose isomerase D. None of these. 55 ATP is a Co-substrate as well as an allosteric inhibitor of A. phospho fructo kinase B. Hexokinase C. Glucokinase D. None of these 56 Complete oxidation of one molecule of Gl. 6 phosphate into CO2 & H2O yields A. 8 ATP equivalent B. 15 ATP equivalent. C. 30 ATP D. 39 ATP 57 End product by glycolysis in erythrocytes is A. lactate B. pyruvate C. PEP D. None of these 58 which of the following enzymes incorporate inorganic phosphate into the substrate ? A. phosphoglycerate kinase B. Gly-3. dehydrogenase C. pyruvate kinase D. Enolase. 59 Citric acid cycle is located in A. Mitochondria B. Cytosol C. both A&B D. ER. 60 Glycerol Can enter glycolytic pathway via: A. Dihydroxy acetone phosphate B. 1,3 Bisphosphoglycerate C. 3 phosphoglycerate D. 2 phosphoglycerate. 61) the formation of citrate from axaloacetate & acetyl CoA is A. Oxidation B. Reduction C Condensation D. Hydrolysis. (62) one molecule of Glucose gives molecules of CO2 in Glycolysis TCA cycle A 6 B. 3 C. 1 D. 2 63) Glycogen phosphorylase liberates the following from. Glycogen A Glucose C. Glucose 1. phosphate B. Glucose. 6. phosphate D. Maltose 64) before Pyruvate enters TCA ·A. Acetyl CoA c. 2. Ketoglutarate cycle it must be converted to B. lactate D. Citrate 65 Glucose. 1. phosphate liberated from glycugen cannot be converted. into free glucose in. A liver B. kidney C. Muscles D. Brain. (66) out of 24 moles of ATP formed in TCA cycle. 2 molecules of ATP level" by which of A. Citric acid B. isocitrale C Succinic acid D. Succinyl COA can be formed at substrate. the following reaction ? isocitric acid axalgaretale fumarate. Succinis acid. Tissues with highest total glycogen content are A. Muscle & kidney B. Kidney & liver C. Liver & muscle D. Brain & liver Which of the following statements regarding TCA cycle is true? A. It is an anaerobic process. B. It occurs in cytosol. C. It contains no intermediates for gluconeogenesis. D. It is amphibolic in nature. The glycolysis is regulated by A. Hexokinase B. Phosphofructo kinase-1 C. Pyruvate kinase D. All of these How many ATP molecules will be required for conversion of 2 molecules of lactic acid to Glucose? A. 2 B. 4 C. 8 D. 6 In presence of the following cofactor, pyruvate Carboxylase converts pyruvate to oxaloacetate: A. ATP, Biotin & CO₂ B. CO2 & ATP C. CO₂ D. Biotin In conversion of lactic acid to Glucose, three of reactions of Glycolytic pathway are circumvented. Which of the following enzymes do not participate? A. pyruvate Carboxylase B. PEP carboxykinase C. pyruvate kinase D. Glucose-6-phosphatase The enzyme involved in phosphorylation of Glucose to Glucose. 6. phosphate are A. Hexokinase B. Glucokinase C. both (A) & (B) D. phosphofructokinase. Synthesis of Glucose from amino acids is termed as A. Glycolysis B. Gluconeogenesis C. Glycogenesis D. lipogenesis. Which one of the following is a rate limiting enzyme of gluconeogenesis ? A. Hexokinase B. phosphofructokinase C. pyruvate carboxylase D. pyruvate kinase The number of ATP produced in succinate dehydrogenase step is A. 1 B. 2 C. 3 D. 4 In glycolysis, synthesis of ATP is catalyzed by one of the following enzymes A. Hexokinase B. phosphoglucose isomerase C. Enolase D. Pyruvate kinase The irreversible reactions of Glycolysis include that catalyzed by A. Aldolase B. Gly. 3. de hydrogenase C. phosphofructokinase 1 D. phosphoglycerate mutase.

MCQ (Carbohydrate Metabolism)

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