Malaria Students Notes

MALARIA MAL AREA CIA- Plasmodium. P. Vivex P. Ovale P. falciparum P. malaria. Digenetic life fogate Cycle life Completed in two host. I host Man 2° host Mosquito. (Female Anophilus) Vector host. Monkey is the Reservoir hast (1° host) Reproduce Ony Asexual In Liver and RBCs. (In Human) Reproduce Sexually as well Asexual In Mosquito, Sporozoit SPOROGONY SALIVA GUT WALL GAMOGONY LUMEN Zygote Schizont merozoit (8-26). meça- Gamont (2) Moxin Rigor & Chill MULTIPLE Cryptozoit NUCLEAR Fission Schizont Sporozoit Pre Erythrocytic Schizogony Merozoit (100-1000) After few Blood Cycle RBC Trophozoit (27) haemozgin Singlet Ring Stage (2n) Amoeboid Stage (2n) Schuffner's, Lzeeman dot Maurars After few Blood Cycle Mega Cryptozoit (64) Post-Erythro Cytic Schizoçony Sporozoit SPOROGONY SALIVA GUT WALL GAMOGONY LUMEN Zygote Microgamont meca-Garmont (2) ERYTHROCYTIC SCHIZOGONY CYCLE Schizont merozoit (8-26). Moxin Rigor & Chill MULTIPLE NUCLEAR Cryptozoit Fiscion Schizont Sporozoit Pre Erythrocytic Schizogony GOLGI CYCLE (48-72 hrs) Merozoit (100-1000) RBC BLOOD CYCLE After few Blood Cycle Trophozoit (2) haemozgin Singlet Ring stage (2n) Amoeboid Stage (2n) Schuffner's, Maurars Zeeman dot Micro (1000-10,000) mega Cryptozo (64) Post-Erythro Cytic Schizoçony After few Blood Cycle Life Cycle of plasmodium In Man- Sporozoit stage of Plamodium is Infective stage for man. Enters in to blood through saliva during Blood Sucking. 1- Pre- Erythrocytic Schizogony. (LIVER) Stort By attack of Sporozoit on Liver Cell, where it forms Cryptozoit undergoes Schizogony & Produce Merozoit Merozoit attack Liver RBC Exo-Crythrocytic Schizojony. 2:- Exo-Erythrocytic Schizogony- (LIVER) RBC Merozoit attack, ELIVER Micro cryptomerozoit Meça Crypto merozoit 3:- Erythrocytic Schizogony (RBC) Trophozoit stage appears In RBC which feed an haemoglobin Trophozoit changes in to Singlet ring Amoeboid→ undergoes Schizosony to Produce Merozoit Jattacks New RBC kla Blood Cycle/Golgi Gycle. At the end of RBC Schizoçong Large amount of toxin (Haemozoin) Releases which is Responsible for Symptoms of Malaria (Rigor & chill →After few Blood Cycle→ Merozoit Enters in Liver & Become Dormant Post Erythrocytic Schizogony In fedure Cause Relapse Malaria After Few Blood Cycle. Trophozoit forms Gametocyte Microgamont Megagamont Development of Gametocyte Is not possible in human Que to High Body temperature Life Cycle of Plasmodium In Mosquito Gametocyte stage of Plasmodium is infective staje for Mosquito SEXUAL PHASE GAMOGONY In Gut Lumen Gametocyte Undergone meiosis to produce Gamete Fusion of Gamete Occur's In GUT LUMEN. ASEXUAL PHASE SPOROGONY Occur's In GUT WALL. Zygote adhere to Gut Wall undergoes Sporogony. to form sporozoit Peritonium wall of Gut ruptures which releases Sporozoit Saliva Symptoms of MALARIA K (0) Prodromal Symptom: Symptoms appear before Actual Clinical Symptoms headache, Anorexia, Insomnia etc. (11) Paroxym clinical Symptom. Rigour-Chill + shivering (No-fever) Febrile -104°F Dafervasent - Sweating & Body temp Normal. (1) Others Anaemia Jaundice Hepatomegaly Types- (1) Tertian malaria -Paroxym on every 3rd day. L Benign P P. vivex P. ovale Malignent -P. falciparum. (11) Quartam malaria Paroxym On every 4th day. - (11) Relapse Malaria ? →P. falciparum Never shows Relapse Malaria.