PAL Worksheet Week 10 Problem Set 1 HORMONAL REGULATION OF BLOOD VOLUME AND OSMOLALITY 1) Name 2 ways by which JG cells can be stimulated to release renin: 1) 2) 2) On your white board, write out the steps involved in the production of angiotensin II starting with renin: 3) What is the ultimate goal of Angiotensin II? - List several functions of angiotensin II: 4) Name one hormone that opposes the actions of angiotensin II: - What is the ultimate goal of this hormone? 5) While on a backpacking trip, Jane consumed some unfiltered lake water, only to wake up the next day with a severe case of diarrhea. As a result of the diarrhea, she was losing water and Na+ through her digestive tract. - Indicate whether the following components (a) increase, (b) decrease, or (c) remain the same, AS A CONSEQUENCE of the diarrhea: _______ Blood volume _______ arterial blood pressure _______ activity of renal sympathetic nerves _______ kidney excretion of Na+ and water - Using the following code, indicate what changes need to take place in Jane’s body, in order to restore her blood volume back to normal: (a) increase, (b) decrease, or (c) no change _______ renin secretion _______ plasma angiotensin II levels _______ aldosterone secretion _______ plasma ANP levels _______ ADH release _______ Na+ reabsorption _______ collecting duct permeability to water _______ water excretion _______ Na+ excretion _______ thirst • Which of the above changes is the only one that can fix Jane’s problem? 6) On a trip to the Grand Canyon with his friends, Dan got separated and lost for about a week (he was eventually found and is OK). During the week alone, he ran out of water after 2 days. - How would Dan’s blood osmolarity compare to normal? - What was his blood ADH levels by the end of the week? Please explain: - Clearly draw and describe the changes in Dan’s urine profile (concentrated/ dilute) and volume (high/low) as the days of the week lost in the desert progressed: