PAL Worksheet Week 7 Problem Set 1 OXYGEN-HEMOGLOBIN DISSOCIATION CURVE 1) What is the most important factor that determines the % saturation of hemoglobin (Hb) with O2? 2) What does it mean when an individual Hb molecule is fully saturated? How is this different from 100% HB saturation? 3) On your white board, draw the Oxygen-hemoglobin dissociation curve. Label the X and Y axes properly. Also, include numbers corresponding to the lungs, tissues at rest and highly metabolically active tissues. 4) What does it mean when the O2-Hb dissociation curve is shifted to the right? Please show this on your graph. 5) List several factors that right-shift the curve: 1) 2) 3) 4) 6) Does right shifting the O2-Hb dissociation curve make it harder or easier for O2 to come off of Hb? 7) Does right shifting the O2-Hb dissociation curve increase or decrease Hb % saturation? 8) Hb has a 210X higher affinity for carbon monoxide than it does for O2. Additionally, CO left shifts the O2-Hb dissociation curve. Please show this change on your graph and also describe how CO poisoning kills an individual: - How can CO poisoning be treated (if caught early)? 9) An individual has a severe case of iron deficiency anemia. How will this affect the oxygenhemoglobin dissociation curve? 10) What is the major form of CO2 transport? How is this chemical generated? (Please write out the equation).