University:
University of Houston
Course:
OPTO 6253 | Practical Pharmacology
Academic year:

2021
Views:

60

Pages:

4
Author:

ilikemyicons0y5

Factors impacting drug absorption through skin • Physicochemical properties of the drug • Biological factors 1 • After completing this lecture, the students ... 1. Know the concept of skin absorption. 2. Understand different methods of drug permeation. 3. Differentiate between iontophoresis and sonophoresis. 4. Understand mechanism of drug permeation. 5. Realize the perfect method for drug permeation. Physicochemical properties of the drug 1. 2. 3. 4. 5. 6. 7. 8. Partition coefficient Molecular size Solubility Melting point pH condition Volatility Charge Base 3 1.Partition coefficient • Drugs possessing both water and lipid solubility are favorably absorbed through the skin. • The transdermal permeability coefficient shows a linear dependence on the partition coefficient. • Varying the vehicle may also alter lipid/water partition coefficient of a drug molecule. 4