Why is PPI the king of anti-secretory agents? * All the 3 receptors (H₂, M3, CCK2/8] act only its theo' PP. So if its blocked then equivalent to blocking all ③ Recepton. How H.pylon causes Gastric Ulcer? H. pylori kills B-cells. No somato statin. There is no block n Gastorn Gautrin will fire more. why it takes (3-5days to achieve max.effect & also. 3-5 days to love effect of PPIs? * At a given pt. of of proton pumps will be by time only 10% will be actue which PP Is. * So H+ it takes 3-5 days to all the purrups & acid suppression takes place. * Illy After Stopping PPIs, it takes 3-5 days to resume nonnal HCl secretn * Efficacy: at All PPIs show Sanie efficacy comparable doces. why PP Is are taken ther before food intake? * Hll secret activates coincides prodrug food intake & Active PPI HCI ←← Absorbed & * 50 only if taken the before, Prodrug will be secreted into parietal cells & will be waiting for food intake. Uses: Rx. (1) PUD (ii) NSAID induced ulcer. (ii) prophylaxis for stress ulcer: (iv) H. pyloric (oc) (v) DC - GERA (vi) DOC - LES (Zollenger Ellison). (vii) (Baret's Esophagus ↓ life Long PPI Rs is reg.