Pharmaerlogy Marmow Serotonin & Related Orig.. 5HT Receptors: types 5HT to 5 HT7. All which is "GPCRs" except ion channel. 5HT3 an. 1) 5HT 1 * Gi presynaptic. * ⇒ Autoreceptors. 5H71A Agonist 5HT1B/1D * CN. present in sero tonergic SHTIA Buspirone Ipsapirone Anxiety Gepirone. Gi SHT (Anxiolytics). CHT 24 Anxiety↑ (sicle eff of SSRIs). Note SSRI give a side effect of Anxiety by SHT2 receptors. (ⅱ) But like when Buspirone Anxiety Uve give SHTan agonists Gi SHT release. (iii) Also Thats SHTIA agonists don't why they عنه TH causa sedation Called A "No Sedation Anxiolytics" 5HT1B SHT2F ganglion →axen of ICN (presynaptic), meningeal ↓ edema. meninges compren highly innervated skull it is & meninges Camus pain (Head Ache (Unilateral) clamically known 01 Migraine. Rx Triptans SHT 18/18 Deloare CORP no varodilato Wo Headache olso cause Vous constric so it treats miginine Nok Triptons not • prophylaxis 'nizatio preceds nigame? Ama pt takes Triptous dewing Auswa we can prevent Attack of migrains then Never drugs for Rx of migraure: SHT1F LASMITIDANS (1) ligand CGRP : approved for Prophylaxis E Eptine zumab. F → Fremanezumab. G → Gelcanezumab.. Migraine Receptos of CGRP neveology Migue related. * Monoclonal Ab Erenumab. * Rimege pant for Approved Rx of Acute migeame. Triptans: MOA: * ↓ CGRP. produce Vaso Constric Use: *only for Rx of Acute attack migraine. [Not for propleylazu] PK & P * All druge differ A lot orally admin. PK & PE Remember if a drug is 31 fortly absorbed then it will be "shost acting" "Slowly absorbed" "loug Acting" Rate of abrospn α. P. action (0) Potency/Effiency to Rx migraine. ie) How much dose is soy depends on how faster its absorbed. songs ahed upon Route.. Oval (24hr) to best for prolonged Attacks. frova triptan V (bhr) Naratripta slow abroyon loing acting Slow Acting Rizatriptan Suma Lolmi Elet Best onl treten fox Acute Attacke fart Short acting fast arting Almo 2 Intranasal Sumatriptan Zolmitspton Subcutaneou & Rectal: Sumatriptans fortest acting Best for Acute Attacks But costlier (non-affordable & lew indely used) Side effects 1) Chest pain bror of Corvinary Vasoconstrict (11) pain Tow Aleck (h) Sweating (1) Andythmia Contra Indicatione Beor those denge they are potest VC. HTN Is hemic do Stroke TIA IBE PVD individual CI: Nova triptans Liver & G failure Eletriptan CI, liven fuiteve. Zelonitriptan. → syndrome.