Ci II) Colchine: MOA Microtubules nigeato of Neutrophils (chemotaxů). Also release of chemotactic factors eg IL-1 Also phagocytosis. User: Acute gout prophylaxis of familial mediterranean fever Amyloidosis Remember So S/E it Microtubules =) Anticancer eff will also be Anticancer S/E such an (1) N&V diarrhoea (m/c) (ii) dose limiting prop. of Anticancer drugs. Bone marrow Suppression. (iii) Alopecia Treatment of chronic Gout Aim To uric à levels. To prevent acute -gout ↓ Synthesis of A) Xanthine oxidase. ↓ ↑ excret of bric à B) Uricosuric drugs metabolism of uric a (Q In birch) C) Usicau analogs 1) Allopurinol. 2) Oxypurinol 3) Febuxostat Sulfinpyrazone Probenacid Benzbromarone 1) Rasaburicase 2) Pegloticare 2) Oxypurinol (ORPHAN DRUG). * Exactly Illan to Allopurinol but don't Cause any Hypersoncitivity, Chronic gout * Orphan rig Hypersemitivity. reserved for pts à Allopurind A 3) Febuxostat: * used only for chronic yout. *S/E Xantreire stores. B) Uriconric Drugs: Indications for this rugs pt. showing No Response for pt under excret of urie a pt Tophi