Introduction to Pharmacokinetics

University:
Virginia Maryland College of Veterinary Medicine
Course:
VM 8164 | The Normal Animal
Academic year:

2023
Views:

112

Pages:

2
Author:

Sarah Landeck

Rearmacetineties what the body does to a Factors affecting t ability to pass a size b protein binding smaller bound protein pass through unbound drugs stay drug through membrane better pass through better in blood until unbound the liver separates drugs from their proteins Solubility lipophilic cross membranes better c ionization d t unionized drugs are lipophilic status pka is when 508 of a drug is ionized PH like is unionized in like concentration gradient most drugs undergo passive diffusion down gradient t drugs that are not lipophilic enough for passive e diffusion IV drug mediated transportation is preferred in the ER because it administration delivery ensures carrier undergo of the drug look absorption Dehydration can decrease subcutaneous absorption Solutions absorb faster than suspensions lipid soluble drugs usually absorb slower feeding a fatty food with a lipid soluble drug can Eternal decrease absorption time absorbed via the GI tract A drug must go into a solution creation bonding of a drug to most before it can be absorb e metal occurs in the small drug absorption First pass metabolism is how much metabolized in gut or liver t trans first pass Graphs a Cma x maximum absorbed drug is circulation transdermal bypass plasma concentration time to Cmax C Area under often and intestine metabolism b Tm ax C Max of an before systemic per rectum mucosal ions curve determines Bioavailability percent Tpintheroddstream of how much magnitude administered bioavailability drug is absorbed of effect drug that show look impossible