Pharmokinetics Drug Distribution - Edubirdie

University:
Virginia Maryland College of Veterinary Medicine
Course:
VM 8164 | The Normal Animal
Academic year:

2023
Views:

460

Pages:

1
Author:

Sarah Landeck

Drug distribution is reversible Drugs move from the plasma blood and EV fluid transfe to the Blood should always be slightly interstitial fluid alkaline drugs ionized basic drugs unionized in blood faster recovery from lipophilic drugs More fat acidic only free drug is active Inflammation Volume of causes distribution increased drug permeation theoretical volume of fluid that a t drug distributes into small Vd means high drug retention Vd must be calculated Younger animals t based on an IV dose have a larger vd and larger dose of water a soluble in plasma therefore need drugs they have less fat and need lower dose of lipophilic

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