Drug Metabolism and Elimination | Virginia Maryland College of Veterinary Medicine

University:
Virginia Maryland College of Veterinary Medicine
Course:
VM 8164 | The Normal Animal
Academic year:

2023
Views:

22

Pages:

2
Author:

Sarah Landeck

AD ME distribution absorption Metabolism conversion of a lipid soluble ataterduble exception is prodrugs which side oral drugs in the gut 7 a phase I b phase I enzymes inhibitors drug to are increase metabolized along are makes drugs more water soluble polar t active form inactive Phases of metabolism elimination metabolism phase II conjugation nonselective concentrations of other drugs inducers decrease them Fast metabolizers in circulation have lower but higher Regearance rate of concentration concentration drug elimination hepatic clearance is dependent on of the drug of metabolites from the body blood flow and intrinsic metabolizing capacity High hepatic clearance drugs are flow limited and have a high concentration of metabolizing enzymes Low hepatic clearance drugs are capacity limited and have low concentrations Mechanisms of renal of enzymes elimination a filtration passive most glomerular filtrate is reabsorbed back into body b tubular active secretion carrier mediated C tubular reabsorption distal tubule drug is eliminated through urine unionized is reabsorbed back into the body through blood Ionized basic drugs are more likely to be reabsorbed