University:
York University
Course:
BIOL 107 | Introduction to Cell Biology
Academic year:

2024
Views:

479

Pages:

2
Author:

Ciara T.

DNA Replication DNA = polymer monomer = nucleotides -> nucleic acid (6) pyrimidines (6,5) purines sugar phosphate N-base Ribose (RNA) has OH compared to Deoxyribose (DNA) aa- peptide bond condensation rxn (phosphodiester bond) = loss of H2O 5'3' is directional phosphate group & hydroxyl (-OH) group Base pairs = A-T and G-C complementary stabilized by H-bonds 53 DNApol I - replaces RNA Continuously = leading DNA ligase - seals the gaps Opening the helix Helicase Catalyzes the breaking of hydrogen bonds between base pairs to open the double helix Leeding-strand synthesis Primase DNA polymerase Catalyzes the synthesis of the RNA primer Extends the leading strand Single-strand DNA-binding proteins (SSBPs) Topoisomerase Stabilizes single-stranded DNA Sliding clamp Holds DNA polymerase in place during strand extension Lagging-strand synthesis Breaks and rejoins the DNA double helix to relieve twisting forces caused by the opening of the helix Primase DNA polymerase A Gatalyzes the synthoom of the RNA primer on an Okazaki fragment Exterids an Okazaki fragment Sliding clamo Holds DNA polymerase in place during strand edension DNA polymeras Removes the RNA primer and replaces it with DINA DNA Catalyzes the joining of Okazaki ragments into a continuous strand