University:
York University
Course:
CHEM 2550 | Pharmacology for Health Sciences
Academic year:

2022
Views:

112

Pages:

1
Author:

Niklas

**Chp 22-pg254** 1. Psychosis Broadly defined as loss of contact of reality, ↑ R/F harm to self & others. -Etiology: Too much dopamine Causes feature of psychiatric disorders, Enbstance alanse, underliging medical disease. 2. Schizophrenia psychiatric disorder involving chronic or reccurent pry choris. -Onset of illness: Adolescence or early adulthood. Positive sx reality distortion sx such as hallucination or delusions. Negating sa "deficit sx ex- expressiveness, apathy, lack of energy. Cognitive impairment: Attention, memory, learning, reasonings are affeced. Antipsychotics All angonize dopamine Typicals: Older drugs (haloperidol); have MAJOR Se's/ADR ; conuse extrapyramidal sx (ePs-parkinson's-typo morements) may cause neuroleptic malignant syndrome (NMS) Typicals antagonize dopamine receptors only. Atypicals: Newer drugs preferred 4 therapy (Aripiprazole); all cause wt. gain, brock dopamine + serotonin 1. HALOPERIDOL-typical antipay cotic attack areas of termin that astral voluntary mwensat 2. Uses: psychotic disorders acute agitation; movement diforders Hunington's disease, tourette's syndrome (tics/ tristeluss). 3.SE: Drowsiness, H/E, photosensitivity, winary retention, Sestival dysfunction orthostatic hypotension. 4. ADR: 6P/NMS EPS Most significant ADR of antipsychotica, particularly typicals Que to blockage of dopamine parkinsonen type 6X Tremens, masted taries, rigidity, shuffling gaik, dystonia, nkatheria, tardare dyskinesia Cirreversible-mudving movement of tace tjou). TX: Anticholinergets: diphenhydramine, ben troping, switch to attypore) NMS Potentially lethal -MEDICAL EMERGENCY ! -Directly caused by antipsychotics -Cause: Unknown. Dopamine receptor blockade destabilizing of sympathetis nervous bystan -5/5 ms's, muscle rigidity, 40'c fever severe hypo/HIN, seizure activity, tachycardia, tachypnea -Tx: Immediate withdrawal of ant psychotit, mydration, cool blanket, bon zo's it seizmas develop. 1. Atypicals-apipriprazde-used 4 long term management of psychorn's, also 4 depressive Ex. 2 Use: Pripslas, major deppressive disorder, schizophronos, Thuretti, antistics ditonder. 356 Pestlessnes or cedation; hyperglycemia, dyslipadema, prots senseirity, sexual dysfubert, ut gain.. 4. ADR Low presillity of EPS/ NMS.. Hematologic abnormalities: Noutrophils ✓ cec fregnently within it for months of therapy, teach of to report signs of infection. 5. Teach pt that initial improvement may be seen in 1-2 weeks but takes the walks to achieve fuel effet.