University:
American Career College
Course:
MICR112 | General Microbiology
Academic year:

2020
Views:

209

Pages:

18
Author:

Callie Nielsen

LI VER AND GALLBLADDER HI STOLOGY LIVER FUNCTIONS GLYCOGEN STORAGE LIPID METABOLISM VITAMIN STORAGE (A, D, B12 ) BILE PRODUCTION (BILE ACIDS SOLUBILIZE LIPIDS AND AID DIGESTION) DETOXIFICATION OF DRUGS AND TOXINS IN SER SYNTHESIS OF PLASMA PROTEINS (ALBUMIN) METABOLISM OF LIPID, CARBOHYDRATE, PROTEINS ERYTHROCYTE BREAKDOWN (BILIRUBIN FORMED IN BREAKDOWN OF RBC) FIGURE 16-11 Copyright © McGraw-Hill Companies Type III collagen that is present in space support lining cells LIVER  LIVER IS THE LARGEST GLAND IN THE BODY, WEIGHING ABOUT 1500 GR ,  IT HAS ENDOCRINE AND EXOCRINE FUNCTIONS  CAPSULE = DENSE IRREGULAR CONNECTIVE TISSUE  PORTAL VEIN: BLOOD OF SMALL INTESTINE (75%)  HEPATIC ARTERIES: OXYGENATED BLOOD (25%)  BULK OF LIVER IS COMPOSED OF HEPATOCYTES LIVER LIVER HAS A LOBULAR ORGANIZATION CLASSICAL LOBULE IN WHICH HEPATOCYTES ARRANGED AS AN HEXAGON PORTAL AREA (TRIAD) HEPATIC ARTERY PORTAL VEIN INTERLOBULAR BILE DUCTS LIVER LOBULES FIGURE 16-18 Copyright © McGraw-Hill Companies Hepatic Acinus lobule Interlobular veins (to hepatic vein) Central vein Sinusoids Bile canaliculi Plates of hepatocytes Bile duct (receives bile from bile canaliculi) Fenestrated lining (endothelial cells) of sinusoids Portal vein (c) Hepatic macrophages in sinusoid walls Bile duct Portal venule Portal arteriole Portal triad LIVER   THE SPACE BETWEEN THE ANASTOMOSING PLATES OF HEPATOCYTES ARE OCCUPIED BY HEPATIC SINUSOIDS SINOSUIDAL LINING CELLS ARE FENESTRATED ARE NOT IN CONTACT WITH EACH OTHER MACROPHAGES KNOWN AS KUPFFER CELLS ASSOCIATED WITH LINING CELLS  THE SPACE THAT SEPARATES SINUSOIDAL LINING CELLS FROM HEPATOCYTES IS CALLED PERISINUSOIDAL SPACE (SPACE OF DISSE)  MICROVILLI OF HEPATOCYTES OCCUPY MUCH OF THE SPACE FIGURE 16-15 Copyright © McGraw-Hill Companies Liver Fat storing cells ( known as Ito cells may present in Disse space and store vitamin A Pit cells which are natural killer cells also may be seen in space of Disse In lateral domain bile canaliculi form between two cells, microvilli, Na-K ATPase and gap junctions are common characteristics of lateral domain Bile canaliculi between hepatocytes leading to hepatic ducts with simple cuboidal epithelium FIGURE 16-17 Copyright © McGraw-Hill Companies Gall Bladder MUCOSA IS LINED BY SIMPLE COLUMNAR EPITHELIUM CELLS HAVE MICROVILLI, NA –K ATPASE PUMP LAMINA PROPRIA IS COMPOSED OF LOOSE CT, SMOOTH MUSCLE LAYER IS COMPOSED OF THIN OBLIQUELY ORIENTED FIBERS WITH PERIMUSCULAR CONNECTIVE TISSUE SEROSAL AND ADVENTITIAL MEMBRANE STORES AND CONCENTRATES 30-50 ML BILE