FEATURES DYSTROPHIC CALCIFICATION METASTATIC CALCIFICATION refinition Deposition of Ca++ salts Deposition of Cat Salts in in dead & deranged tissues, normal tissues due to hypercalcemia ea Metabolism Normal Deranged Serum Ca+ level Normal Hypercal cemia (T) Site of calcificate Locally, to the injured site May be wide spread throughout the body. Cause Cell injury or Necrosis Increase in blood ca+ level due to: intake of Ca2+ in secretion of PTH (e.g; Parathyroid tumss) Destruction of bones mobilization of Ca2+ from bones) Vitamin-D intoxication Phosphate retention due to renal failure (2° Pathogenesis Phosphate accumulate Increase deposition in the injured tissue at of calcium phosphates the site of necrosis, due to hypercalcemia which in turn binds to in somewhat normal Ca2+, forming calcium- tissues or organs e.g; phosphate precipitates Kidney, lugs, Gastric- mucosa etc. Examples -Old - scars (calified) -Renal stones - Aortic valve stenosis - Metastatic calcificatio - Calcification at of Kidney lungs the site of fat gastric mucosa and necrosis. arteries

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