Tolerance Autoimmunity Test 2 Questions and Solutions

✔ - right answer Question 1 Type I hypersensitivity includes the following: ● ✔ ✔ ● Hay fever Contact dermatitis Anaphylaxis Urticaria Question 2 Select the correct statements: ● in the first inflammatory phase, maternal HILA-I regulates the interaction between NK cells and trophoblast to establish the blood supply to the placenta ✔ in the anti-inflammatory state, the HLA-G molecule produced by the trophoblast has an immunomodulatory effect ● Inflammatory mediators produced by decidual dendritic cells are necessary for blastocysta implantation ✔ during pregnancy, a shift of the immune response towards TH2 is observed Question 6 Which of the following statements are true? ✔ The goal of the PD-1 / PD-L1 blockade is the free association of CD28 and 87 receptors. ● The PD-1 / PD-L1 blockade ensures the function of CTLA-4. ✔ Beta-carotene may, under certain conditions, contribute to the progression of respiratory tumors. ✔ During tumorigenesis, the balance between the function of protooncogenes and tumor suppressor genes is upset, while external carcinogens can also affect the function of other genes. Question 8 The following are used as treatment strategies for type I hypersensitivity reactions: ● ✔ ✔ ● blocking of binding of IgE to mastcells by monocional antibodies block mediators with antihistamine avoidance of allergen administration of antibiotics Question 10 During the antitumor response: ● ✔ ✔ ● Cross-presentation takes place MHCII antigen presentation occurs no antigen presentation and therefore no effective antitumor immune response MHCI antigen presentation occurs Question 11 Which of the effector functions are characteristic for Tregs? ✔ cytotoxicity ✔ phagocytosis ✔ IL-2 production ● production of inhibitory cytokines Question 14 Which of the following are characteristic for regulatory T-cells? ✔ in the given microenvironment CD4+ T-cells can differentiate to Tregs upon recognition of self antigens ✔ they produce T-cell activating cytokines ● memory Tregs can develop ● CD4+ CD23+ FoxP3+ phenotype Question 19 The following examples for type IlI hypersensitivity reactions: ● ● ✔ ✔ Haemolytic transfusion reaction Arthus reaction systemic lupus erythematosus Serum disease Question 20 Which of the following statements are true? ✔ ✔ ● ● plasma cells produce igA against helminths. antigenic drift helps making better vaccines against viruses viruses evade immune responses by producing decoy MHC molecules Intracellular bacteria can escape the pathogen killing mechanisms of macrophages Question 22 It is true for the ADCC that: ✔ ✔ ● ● antibody-Fc receptor binding macrophages are involved in the process requires specific function of B cells only works in Rh+ individuals Question 23 Cytotoxic T cells play role in the pathogen defence by: ✔ ● ● ✔ recognition of foreign antigens in complex with MC I Destroying of macrophages infected with Listeria monocytogenes lysis of the opsonized bacteria destroying all virus-infected cells Question 24 Which of the following are characteristics for tolerogenic immune response? ✔ ● ✔ ✔ appearance of inhibitory antibodies characteristics of reactive lymphocytes results in tolerance of selt-antigens triggered by autogenic antigens Question 26 Which of them can play role in development of autoimmune response? ✔ ✔ ● ● exacerbated activity of the immune cells molecular mimicry alteration of autoantigens (e.g. structural changes) induction of PAMP and/or DAMP Question 27 Intracellular pathogens can activate: ● ✔ ✔ ● Interferon production The regulator function of NK cells ROS production by macrophages Expression of antiapoptotic proteins