University:
Boston University
Course:
CAS CH 373 | Principles of Biochemistry
Academic year:

2023
Views:

320

Pages:

2
Author:

StellarStrategist

Synthesis of thyroid hormones Plasma trapping oxidation I peroxidase I₂+ TG H₂O iodination HIT DIT Coupling MIT DIT bound T TGOTG storage by endolytosic release storage vesicle, F: 16% T90% active, short duration Plasma baund to ***globulin (TBG) Albumin (TBA) Target Sites Steps 1. Iodide pump (iodide trapping):. (Lone) Chigh come • Iodide (I) is transported from blood to thyroid cells by NIS [Co transpor ter er 2º active trasport]. • Iodide is Concentrated in the Cells (30-250 times). • NIS کا by TSH by anion-dregs (perchlorate, thiocyanate) Chaikoff- phenmenen Continous use Early NIS due ↑ I in blood to Tuptake Later Nis due to high I in the Cells." 2. Oxidation of Iodide: * Peroxidase I Iz (lodide) H2Q 2 (iodine) * Rate limiting enzyme. * Cu is Cofactor * peroxidase is by ISH by Thiourea dings (Propyl this trail) 3. Lodination or Organification: TGI 3.5 →MIT DIT 4. Capling MIT DIT 13 PIT DITT r.T ?? 5. Bound to TG 6. Storage inside Cell in Vesicles by Gidarytosis. 7. Release