University:
Boston University
Course:
CAS CH 373 | Principles of Biochemistry
Academic year:

2023
Views:

268

Pages:

7
Author:

StellarStrategist

Thyroid gland Anatomy- foand in Ant neck Belowand Ant to LArynex. one of Largest Endocrin gland. Cartylage Thyroid gland 15-20 gram in Adult Trachea Secret-T3-T4-calcitonin Ca Regulated By hypothalamus and pitatarg axies. TRHTSH" Negative Feed Back Notessintail for Life But Important for (metabolism & growth) Histology- .consist of thyroid follical. eash follical consist of cuboidal cell called follicular cell-7T3-T4. Inside follical there in colloid=> thyroglobulin. Storge=>3 month. -THYROID FOLLICULAR COLLOID Para follicular cell _ccell Secret calcitonin. *Thyroid Hormones:- Thus Tetra Lodinthyronin [L 3,6 3.5]. T3Tri Indin thyronin [13,6,3]. Reverse T3 (13,3,5] Inactive ve404 mare in tissue more in blood avee potent Less potent Less daration more duration (72) Synthesis of Tr 0 Iodid Trapping [indid pump les co. Transport Nas Zaby Active Trans part. Oxidation of Ladidas Iodio. Peroxidase) TS! Borganization of Ia din. Il Tyrosin MIT. 212 TrenDIT. copling DIT+MITTS, DIT DITT 5) Storge Ts+Te Attached thyoglobulin collod. Releas TSH (Protera) Tissue MIT DIT Thyvaglobin (Pratera collid Follicular cell 7) Transport Attiched Highly to plasma protein Free. minly TBG cliver) alse Albamin, Intissue Te mechanism of cell K most of cell In body have thymid K. Nuclain Receptor. Enter thought pars need ATP. Attched to DNA lead to Activate of Inhibit Specific gene. *Substant and Drag Inkist thyroid stimulatum OTkocgnate perchorchal. Iodid pump.. prepytagronical PT peroxidase. High dose of Iadid. 4) Vegelubuls. Function of action of T3_T4 @metabolic Action BMR (Basal meta bolic Rade). Normale 5%-1BMR-I metabolism. ATP hydrolysis-tos consumption. heat Production. 2CHo (Hyperglycemia) I absorption GGIT Glycogomelysis-161G.. insulin. Uptake of Gutilizatioco cells ATP. 3) lipid (Lipolysis). THDL F.FA Bleed uptake FFA celles ATP cholestrol Blood.LTAG.ILDL 4) Proteins (Anabolic) (Normal Range) catabolic (GIG) 5) Vitamin Bicarlonin vil.A. Function of action of T3_T4 @metabelic Action BMR (Basel mota bolic Rade), Normal 5%-18MR-I metabolism. ATP ingdrolysis as consumption. heat Production. 2CHo (Hyperglycemia) I absorption G-GIT Glycogomelysis IG IG. 1insulin. Uptake of Gutilizate cell ATP. lipid (Lipolysis). PHOL F.FA Bleed uptake F.FA ascellas ATP cholestrol Bloed.LTAGILDL 4) Proteins (Anabolic) (Normal Range) catabolic (GIG) 5) Vitamin Bcartoninvil. A. *Systemier cvs TH.R.COP.T SBP- Plase pressure-IDBP-V.D Respiratury las consumption. I R.R Hyperventalation Sheft curve to RT CNS myiin Sheat-Benwer temnor. Repro Jastive Develpmut Reproducivel, 5) Endocrine: (Permissive Effect). Eye Vit A Night) GIT Wt gain fetal Develpment. Growth Nural Develpment 01 miyline Sheat Synap-INT. SomaticDevoipment Imuscle-Bone-Icartilage. SexualDevelpments (1ry Sexual organ male and female)