University:
Boston University
Course:
GRS CH 644 | Medicinal Chemistry
Academic year:

2023
Views:

440

Pages:

3
Author:

StellarSymphony

Etliane n-Butane Cau be Comparcable with the structure of ethane in which one hydrogen atom from each of Carbon atom has been replaced by the methyl group. Therefore different Conformation of n-butane are Possible by fixing one Carbon atorm & rotating the other. The Carrotation is Carried out by using formula through an angle of 60 as below :- CH newmann Projecti ↳ Structure I is Completely or fully staggered or auti fors because -ch groups are fare apart from each other. ↳ Structure IV is fully eclipsed because - its groups arce Very closed to each other. → Structure II and arce Partially staggered ore skew form where as Structure II and VI arce Partially eclipsed. Energy Profile diagram for n-butane Cau be represented -50 From energy Profile diagram. 1. The C-ch bonds being closest, there will be maximum repulsion in fully eclipsed form. Hence, its energy is maxim (Structure-1) 2. The C-ct bonds being far apart, there will be minimum repulsion in fully staggerred foron. Hence it's energy is minimum (Structuree-I) 3. The C-CH bonds being Go apart, there will be Dome repulsion in Skew form as Compared to anti form. Hence its energy will be more than antiform. (Structure II,Y) 4. The C-ch bonds being 120° apart, there will be still mare repulsion being loose like eclipsed foam. Hence its energy will be more from Skew form. (Structure-I, avi) 5. The Oadea of stability of different conformation of ri-butan is:- Fully staggered < Skew forn < Partially eclipsed < (1) (Ⅱ, νι) fully eclipsed!" < (1.) (IV)